Wai-Tong Ng1, Edwin C Y Wong1, Alice K W Cheung2, James C H Chow3, Darren M C Poon4, Jessica W Y Lai5, Chi-Leung Chiang6, Horace C W Choi6, Tin-Ching Chau6, Victor H F Lee6, Anne W M Lee6, Anthony H P Tam7, Kwok-Hung Au3. 1. Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China. 2. Department of Clinical Oncology, Tuen Mun Hospital, Hong Kong, China. 3. Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China. 4. Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong, China. 5. Department of Clinical Oncology, Princess Margaret Hospital, Hong Kong, China. 6. Department of Clinical Oncology, Li Ka Shing Faulty of Medicine, The University of Hong Kong, Hong Kong, China. 7. The Hong Kong Cancer Registry, Hospital Authority, Hong Kong, China.
Abstract
BACKGROUND: This study evaluates the contemporary care for patients with locally recurrent nasopharyngeal carcinoma after failure of the primary course of intensity modulated radiotherapy. METHODS: Eligible patients were identified through the Hong Kong Cancer Registry database. Patterns of care and treatment outcomes were analyzed. RESULTS: Two hundred seventy-two patients with locally recurrent tumors were identified. Of them, 30.9% received surgery, whereas 35.7% received re-irradiation (re-RT). The 5-year overall survival (OS) for the whole group was 30.2%. Old age and advanced rT classification were adverse prognostic factors, whereas surgery (mainly in resectable recurrence) was associated with favorable survival outcome. The 5-year OS rates for patients who received surgery and re-RT were 56.3% and 21.8%, respectively. CONCLUSIONS: Early detection of resectable recurrence is of paramount importance as surgery for resectable tumors offers the potential to achieve excellent outcomes. Re-RT could be considered in selected patients with unresectable disease and favorable prognostic features.
BACKGROUND: This study evaluates the contemporary care for patients with locally recurrent nasopharyngeal carcinoma after failure of the primary course of intensity modulated radiotherapy. METHODS: Eligible patients were identified through the Hong Kong Cancer Registry database. Patterns of care and treatment outcomes were analyzed. RESULTS: Two hundred seventy-two patients with locally recurrent tumors were identified. Of them, 30.9% received surgery, whereas 35.7% received re-irradiation (re-RT). The 5-year overall survival (OS) for the whole group was 30.2%. Old age and advanced rT classification were adverse prognostic factors, whereas surgery (mainly in resectable recurrence) was associated with favorable survival outcome. The 5-year OS rates for patients who received surgery and re-RT were 56.3% and 21.8%, respectively. CONCLUSIONS: Early detection of resectable recurrence is of paramount importance as surgery for resectable tumors offers the potential to achieve excellent outcomes. Re-RT could be considered in selected patients with unresectable disease and favorable prognostic features.
Authors: Wing Lok Chan; James Chung Hang Chow; Zhi-Yuan Xu; Jishi Li; Wing Tung Gobby Kwong; Wai Tong Ng; Anne W M Lee Journal: Front Oncol Date: 2022-02-01 Impact factor: 6.244