Eugenia Gkaliagkousi 1 , Eleni Gavriilaki 1 , Ioannis Vasileiadis 2 , Barbara Nikolaidou 1 , Efthalia Yiannaki 3 , Antonios Lazaridis 1 , Areti Triantafyllou 1 , Panagiota Anyfanti 1 , Dimitra Markala 3 , Ioannis Zarifis 2 , Stella Douma 1 Show Affiliations »
Abstract
BACKGROUND: Endothelial microvesicles (EMVs) have emerged as markers of endothelial injury. However, little is known about their levels in the coronary circulation of acute coronary syndrome (ACS) and stable coronary artery disease (CAD). We hypothesized that ACS patients exhibit a more pronounced increase of EMVs both in the peripheral and coronary circulation when compared with CAD. We also investigated possible associations of EMVs with markers preclinical target organ damage. METHODS: We enrolled consecutive eligible patients undergoing coronary angiography. Blood samples were collected from the stem of the left coronary artery and the femoral artery. ΕMVs were measured by a standardized flow cytometry protocol. Central systolic blood pressure (cSBP) was measured invasively and patients' history was recorded. RESULTS: CAD patients exhibited increased levels of EMVs compared with controls. When patients with ACS and stable CAD were compared, the former had significantly increased EMVs in both coronary and peripheral circulation. Importantly, both ACS and CAD patients exhibited increased levels of EMVs in the coronary circulation compared with periphery. In addition, EMVs were associated with cSBP. CONCLUSIONS: EMVs emerge as novel markers of ongoing underlying vascular damage, further augmenting the vicious cycle of inflammation and thrombosis mainly in ACS but also in stable CAD. © American Journal of Hypertension, Ltd 2019. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
BACKGROUND: Endothelial microvesicles (EMVs) have emerged as markers of endothelial injury . However, little is known about their levels in the coronary circulation of acute coronary syndrome (ACS) and stable coronary artery disease (CAD). We hypothesized that ACS patients exhibit a more pronounced increase of EMVs both in the peripheral and coronary circulation when compared with CAD. We also investigated possible associations of EMVs with markers preclinical target organ damage. METHODS: We enrolled consecutive eligible patients undergoing coronary angiography. Blood samples were collected from the stem of the left coronary artery and the femoral artery. ΕMVs were measured by a standardized flow cytometry protocol. Central systolic blood pressure (cSBP) was measured invasively and patients ' history was recorded. RESULTS: CAD patients exhibited increased levels of EMVs compared with controls. When patients with ACS and stable CAD were compared, the former had significantly increased EMVs in both coronary and peripheral circulation. Importantly, both ACS and CAD patients exhibited increased levels of EMVs in the coronary circulation compared with periphery. In addition, EMVs were associated with cSBP. CONCLUSIONS: EMVs emerge as novel markers of ongoing underlying vascular damage , further augmenting the vicious cycle of inflammation and thrombosis mainly in ACS but also in stable CAD. © American Journal of Hypertension, Ltd 2019. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Entities: Disease
Species
Keywords:
acute coronary syndrome; blood pressure; coronary artery disease; endothelial; hypertension; microvesicles
Year: 2019
PMID： 31350539 DOI： 10.1093/ajh/hpz116
Source DB: PubMed Journal: Am J Hypertens ISSN： 0895-7061 Impact factor: 2.689