Literature DB >> 3134969

Impairment of endothelium-dependent relaxation in aortae from spontaneously diabetic rats.

W Durante1, A K Sen, F A Sunahara.   

Abstract

1. Diabetes mellitus is known to produce alterations in vascular reactivity. The present study examined the effects of endothelium-dependent and endothelium-independent relaxing substances on thoracic aorta from control and spontaneously diabetic rats. 2. Endothelium-dependent relaxation produced by acetylcholine or the calcium ionophore, A23187, in aortic rings precontracted with phenylephrine was significantly attenuated in diabetic vessels. 3. Relaxations produced by sodium nitroprusside or adenosine in diabetic preparations were comparable to those in control vessels. 4. The results show that diabetes leads to a specific impairment of endothelial-dependent relaxation.

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Year:  1988        PMID： 3134969      PMCID： PMC1854002          DOI： 10.1111/j.1476-5381.1988.tb11548.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  24 in total

1.  Increased alpha 2-adrenoreceptor mediated vascular contraction in diabetic rats.

Authors:  N L Scarborough; G O Carrier
Journal:  J Auton Pharmacol       Date:  1983-09

Review 2.  Role of endothelium in responses of vascular smooth muscle.

Authors:  R F Furchgott
Journal:  Circ Res       Date:  1983-11       Impact factor: 17.367

3.  Effects on prostaglandins F2 alpha, I2, and indomethacin on isolated coronary arteries from healthy and alloxan-diabetic dogs.

Authors:  I Palik; P Hadházy; K Magyar; B Malomvölgyi; M Wagner; G Pogátsa
Journal:  Experientia       Date:  1981

4.  Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries.

Authors:  J G De Mey; P M Vanhoutte
Journal:  J Physiol       Date:  1981-07       Impact factor: 5.182

5.  Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

Authors:  R M Rapoport; F Murad
Journal:  Circ Res       Date:  1983-03       Impact factor: 17.367

6.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.

Authors:  R F Furchgott; J V Zawadzki
Journal:  Nature       Date:  1980-11-27       Impact factor: 49.962

7.  Decreased endothelium-dependent relaxation in New Zealand genetic hypertensive rats.

Authors:  R J Winquist; P B Bunting; E P Baskin; A A Wallace
Journal:  J Hypertens       Date:  1984-10       Impact factor: 4.844

8.  The effects of sympathetic stimulation and adenosine on coronary circulation and heart function in diabetes mellitus.

Authors:  M Z Koltai; G Jermendy; V Kiss; M Wagner; G Pogátsa
Journal:  Acta Physiol Hung       Date:  1984

9.  Insulin reversal of diabetes-induced inhibition of vascular contractility in the rat.

Authors:  M A Pfaffman; C R Ball; A Darby; R Hilman
Journal:  Am J Physiol       Date:  1982-04

10.  Endothelium-induced relaxation by acetylcholine associated with larger rises in cyclic GMP in coronary arterial strips.

Authors:  S Holzmann
Journal:  J Cyclic Nucleotide Res       Date:  1982
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  44 in total

1.  Chronic exposure to high glucose impairs bradykinin-stimulated nitric oxide production by interfering with the phospholipase-C-implicated signalling pathway in endothelial cells: evidence for the involvement of protein kinase C.

Authors:  Y Tang; G D Li
Journal:  Diabetologia       Date:  2004-12-15       Impact factor: 10.122

2.  Alterations in atrial reactivity in a strain of spontaneously diabetic rats.

Authors:  W Durante; F A Sunahara; A K Sen
Journal:  Br J Pharmacol       Date:  1989-08       Impact factor: 8.739

3.  Diabetic eNOS-knockout mice develop accelerated retinopathy.

Authors:  Qiuhong Li; Amrisha Verma; Ping-Yang Han; Takahiko Nakagawa; Richard J Johnson; Maria B Grant; Martha Campbell-Thompson; Yagna P R Jarajapu; Bo Lei; William W Hauswirth
Journal:  Invest Ophthalmol Vis Sci       Date:  2010-04-30       Impact factor: 4.799

4.  Early and intermediate Amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature.

Authors:  L Rodríguez-Mañas; J Angulo; S Vallejo; C Peiró; A Sánchez-Ferrer; E Cercas; P López-Dóriga; C F Sánchez-Ferrer
Journal:  Diabetologia       Date:  2003-03-12       Impact factor: 10.122

5.  Vasoreactivity and prostacyclin release in streptozotocin-diabetic rats: effects of insulin or aldose reductase inhibition.

Authors:  E J Stevens; G B Willars; P Lidbury; F House; D R Tomlinson
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

Review 6.  Endothelial nitric oxide (NO) and its pathophysiologic regulation.

Authors:  Anuran Chatterjee; Stephen M Black; John D Catravas
Journal:  Vascul Pharmacol       Date:  2008-07-20       Impact factor: 5.773

7.  Hydroxyl radicals mediate injury to endothelium-dependent relaxation in diabetic rat.

Authors:  G M Pieper; P Langenstroer; G J Gross
Journal:  Mol Cell Biochem       Date:  1993-05-26       Impact factor: 3.396

8.  Pharmacological manipulation of vascular endothelium function in non-diabetic and streptozotocin-diabetic rats: effects on nerve conduction, hypoxic resistance and endoneurial capillarization.

Authors:  N E Cameron; M A Cotter; K C Dines; E K Maxfield
Journal:  Diabetologia       Date:  1993-06       Impact factor: 10.122

Review 9.  The role of serotonin in the preeclampsia-eclampsia syndrome.

Authors:  C P Weiner
Journal:  Cardiovasc Drugs Ther       Date:  1990-01       Impact factor: 3.727

10.  Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: role of polyol pathway.

Authors:  N E Cameron; M A Cotter
Journal:  Diabetologia       Date:  1992-11       Impact factor: 10.122
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