Literature DB >> 3134968

Antihaemophilic effect of vasopressin, deamino-(D-arginine8)-vasopressin and adrenaline in sheep: proposal for an in vivo assay system.

J Heiniger1, L Kissling-Albrecht, S Neuenschwander, R Rösli, V Pliska.   

Abstract

Female sheep were used to assay antihaemophilic (factor VIII enhancing) activity of arginine vasopressin, deamino-(D-arginine8)-vasopressin (DDAVP) and adrenaline. The time course of the response was biphasic, two surges of factor VIII being observed. DDAVP was found to be the most potent of the substances investigated. Its optimal dose was 1 microgram kg-1 body wt (i.v.). It is suggested that a similar procedure can be employed to search for new peptides with anti-haemophilic action.

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Year:  1988        PMID： 3134968      PMCID： PMC1853979          DOI： 10.1111/j.1476-5381.1988.tb11525.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  Increase in antihaemophilic globulin activity following infusion of adrenaline.

Authors:  G I INGRAM
Journal:  J Physiol       Date:  1961-04       Impact factor: 5.182

2.  Hormonal and cardiovascular responses to DDAVP in man.

Authors:  T D Williams; S L Lightman; M J Leadbeater
Journal:  Clin Endocrinol (Oxf)       Date:  1986-01       Impact factor: 3.478

3.  Specificity in the factor VIII response to vasopressin infusion in man.

Authors:  C V Prowse; G Sas; A M Gader; J H Cort; J D Cash
Journal:  Br J Haematol       Date:  1979-03       Impact factor: 6.998

4.  Plasma concentrations of factor VIII after administration of DDAVP to conscious dogs.

Authors:  H Vilhardt; T Barth; J Falch; I M Nilsson
Journal:  Thromb Res       Date:  1987-09-01       Impact factor: 3.944

5.  Mechanism of plasminogen activator and factor VIII increase after vasoactive drugs.

Authors:  P M Mannucci; M Aberg; I M Nilsson; B Robertson
Journal:  Br J Haematol       Date:  1975-05       Impact factor: 6.998

6.  The effect of desamino-D-arginine vasopressin (DDAVP) and naloxone infusions on factor VIII and possible endothelial cell (EC) related activities.

Authors:  E H Moffat; J C Giddings; A L Bloom
Journal:  Br J Haematol       Date:  1984-08       Impact factor: 6.998
  6 in total

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