| Literature DB >> 3134918 |
K M De Cock1, R Colebunders, H Francis, N Nzilambi, M Laga, R W Ryder, M Bondjobo, J B McCormick, P Piot.
Abstract
The clinical case definition for AIDS proposed by WHO for use in Africa was evaluated against HIV antibody status in 72 patients in rural Zaire. Twenty-one (29%) of the patients were antibody-positive. For diagnosing anti-HIV seropositivity, the case definition had a sensitivity of 52%, a specificity of 78%, a positive predictive value of 50% and a negative predictive value of 80%. Calculation of the positive predictive value at different levels of prevalence of HIV infection suggests that the case definition operates at maximum reliability in selected high-risk groups. Modifications to the case definition should be evaluated to try and improve its sensitivity and positive predictive value.Entities:
Keywords: Acquired Immunodeficiency Syndrome; Africa; Africa South Of The Sahara; Age Factors; Developing Countries; Diseases; Examinations And Diagnoses; French Speaking Africa; Hiv Infections; Middle Africa; Prevalence; Viral Diseases; Who; Zaire
Mesh：
Year: 1988 PMID： 3134918
Source DB: PubMed Journal: AIDS ISSN： 0269-9370 Impact factor: 4.177