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Literature DB >> 31349127

Imaging of post-mortem human brain tissue using electron and X-ray microscopy.

Amanda J Lewis¹, Christel Genoud², Mélissa Pont¹, Wilma Dj van de Berg³, Stephan Frank⁴, Henning Stahlberg⁵, Sarah H Shahmoradian⁶, Ashraf Al-Amoudi¹.

Abstract

Electron microscopy imaging of post-mortem human brain (PMHB) comes with a unique set of challenges due to numerous parameters beyond the researcher's control. Nevertheless, the wealth of information provided by the ultrastructural analysis of PMHB is proving crucial in our understanding of neurodegenerative diseases. This review highlights the importance of such studies and covers challenges, limitations and recent developments in the application of current EM imaging, including cryo-ET and correlative hybrid techniques, on PMHB.

Entities: Chemical Disease Species

Year: 2019 PMID： 31349127 DOI： 10.1016/j.sbi.2019.06.003

Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809

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Cited

7 in total

1. Multimodal Brain Imaging Fusion for the White-Matter Fiber Architecture in the Human Brain.

Authors: Ming Song; Zhengyi Yang; Tianzi Jiang
Journal: Neurosci Bull Date: 2022-01-31 Impact factor: 5.203

2. Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.

Authors: Ricardo Guerrero-Ferreira; Nicholas Mi Taylor; Ana-Andreea Arteni; Pratibha Kumari; Daniel Mona; Philippe Ringler; Markus Britschgi; Matthias E Lauer; Ali Makky; Joeri Verasdonck; Roland Riek; Ronald Melki; Beat H Meier; Anja Böckmann; Luc Bousset; Henning Stahlberg
Journal: Elife Date: 2019-12-09 Impact factor: 8.140

3. Axonal mitochondria adjust in size depending on g-ratio of surrounding myelin during homeostasis and advanced remyelination.

Authors: Benjamin V Ineichen; Keying Zhu; Karl E Carlström
Journal: J Neurosci Res Date: 2020-12-25 Impact factor: 4.164

4. FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade.

Authors: Pierre De Rossi; Amanda J Lewis; Johanna Furrer; Laura De Vos; Tomas Demeter; Aurélie Zbinden; Weijia Zhong; Vera I Wiersma; Carlo Scialo; Julien Weber; Zhongning Guo; Stefano Scaramuzza; Marta Di Fabrizio; Carolin Böing; Daniel Castaño-Díez; Ashraf Al-Amoudi; Manuela Pérez-Berlanga; Tammaryn Lashley; Henning Stahlberg; Magdalini Polymenidou
Journal: EMBO Rep Date: 2021-11-22 Impact factor: 8.807

Imaging of post-mortem human brain tissue using electron and X-ray microscopy.

1. Multimodal Brain Imaging Fusion for the White-Matter Fiber Architecture in the Human Brain.

2. Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.

3. Axonal mitochondria adjust in size depending on g-ratio of surrounding myelin during homeostasis and advanced remyelination.

4. FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade.

Review 5. Imaging Synaptic Density: The Next Holy Grail of Neuroscience?

6. Reconstruction of ovine axonal cytoarchitecture enables more accurate models of brain biomechanics.

7. Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution.