| Literature DB >> 31348518 |
Christel Gérardin1,2, Anissa Moktefi2,3, Cécile Couchoud4, Alyette Duquesne5, Nacera Ouali6, Philippe Gataut7, Alexandre Karras8, Dany Anglicheau9,10, Carmen Lefaucheur11, Lucile Figueres12, Laetitia Albano13, Arnaud Lionet14, Marine Novion15, Marie-Julia Ziliotis16, Magali Louis17, Arnaud Del Bello18, Marie Matignon1,2, Karine Dahan19, Anoosha Habibi20,21, Frederic Galacteros20,21, Pablo Bartolucci20,21, Philippe Grimbert1,2, Vincent Audard1,2.
Abstract
The prognosis of sickle cell disease (SCD) patients who need dialysis is poor, but experience with kidney transplantation is limited. This study assessed the characteristics of 36 SCD patients undergoing renal transplantation. Immediate post-surgical complications occurred in 25% of cases. Cytomegalovirus and bacterial infections were frequently observed. Twelve patients died after a median follow-up period of 17·4 months. Overall patient survival was significantly lower in SCD than in the control group without significant difference for overall death-censored graft survival. Our data suggest that renal transplantation should be systematically considered in SCD patients with end-stage renal disease.Entities:
Keywords: infections; patient survival; renal transplantation; sickle cell disease
Year: 2019 PMID： 31348518 DOI： 10.1111/bjh.16113
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998