Susan R Criswell1, Susan Searles Nielsen, Mark N Warden, Hubert P Flores, Jason Lenox-Krug, Sophia Racette, Lianne Sheppard, Harvey Checkoway, Brad A Racette. 1. Department of Neurology, Washington University School of Medicine, St. Louis, Missouri (Dr Criswell, Dr Nielsen, Mr Warden, Mr Flores, Mr Lenox-Krug, Ms Racette, and Dr Racette); Department of Environmental and Occupational Health Sciences, University of Washington, School of Public Health, Seattle, Washington (Dr Sheppard); Department of Biostatistics, University of Washington, School of Public Health, Seattle, Washington (Dr Sheppard); Department of Family Medicine and Public Health, UC San Diego School of Medicine, La Jolla, California (Dr Checkoway); Department of Neurosciences, UC San Diego School of Medicine, La Jolla, California (Dr Checkoway); School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa (Dr Racette).
Abstract
OBJECTIVE: T1-weighted brain magnetic resonance imaging (MRI) of the basal ganglia provides a noninvasive measure of manganese (Mn) exposure, and may also represent a biomarker for clinical neurotoxicity. METHODS: We acquired T1-weighted MRI scans in 27 Mn-exposed welders, 12 other Mn-exposed workers, and 29 nonexposed participants. T1-weighted intensity indices were calculated for four basal ganglia regions. Cumulative Mn exposure was estimated from work history data. Participants were examined using the Unified Parkinson's Disease Rating Scale motor subsection 3 (UPDRS3). RESULTS: We observed a positive dose-response association between cumulative Mn exposure and the pallidal index (PI) (β = 2.33; 95% confidence interval [CI], 0.93 to 3.74). There was a positive relationship between the PI and UPDRS3 (β = 0.15; 95% CI, 0.03 to 0.27). CONCLUSION: The T1-weighted pallidal signal is associated with occupational Mn exposure and severity of parkinsonism.
OBJECTIVE: T1-weighted brain magnetic resonance imaging (MRI) of the basal ganglia provides a noninvasive measure of manganese (Mn) exposure, and may also represent a biomarker for clinical neurotoxicity. METHODS: We acquired T1-weighted MRI scans in 27 Mn-exposed welders, 12 other Mn-exposed workers, and 29 nonexposed participants. T1-weighted intensity indices were calculated for four basal ganglia regions. Cumulative Mn exposure was estimated from work history data. Participants were examined using the Unified Parkinson's Disease Rating Scale motor subsection 3 (UPDRS3). RESULTS: We observed a positive dose-response association between cumulative Mn exposure and the pallidal index (PI) (β = 2.33; 95% confidence interval [CI], 0.93 to 3.74). There was a positive relationship between the PI and UPDRS3 (β = 0.15; 95% CI, 0.03 to 0.27). CONCLUSION: The T1-weighted pallidal signal is associated with occupational Mn exposure and severity of parkinsonism.
Authors: Y Kim; K S Kim; J S Yang; I J Park; E Kim; Y Jin; K R Kwon; K H Chang; J W Kim; S H Park; H S Lim; H K Cheong; Y C Shin; J Park; Y Moon Journal: Neurotoxicology Date: 1999-12 Impact factor: 4.294
Authors: Eun-Young Lee; Michael R Flynn; Guangwei Du; Mechelle M Lewis; Rebecca Fry; Amy H Herring; Eric Van Buren; Scott Van Buren; Lisa Smeester; Lan Kong; Qing Yang; Richard B Mailman; Xuemei Huang Journal: Toxicol Sci Date: 2015-05-07 Impact factor: 4.849
Authors: S R Criswell; J S Perlmutter; T O Videen; S M Moerlein; H P Flores; A M Birke; B A Racette Journal: Neurology Date: 2011-04-06 Impact factor: 9.910
Authors: Brad A Racette; Susan Searles Nielsen; Susan R Criswell; Lianne Sheppard; Noah Seixas; Mark N Warden; Harvey Checkoway Journal: Neurology Date: 2016-12-28 Impact factor: 9.910
Authors: Elza Rechtman; Paul Curtin; Lynn C Onyebeke; Victoria X Wang; Demetrios M Papazaharias; Danielle Hazeltine; Erik de Water; Ismail Nabeel; Venkatesh Mani; Norman Zuckerman; Roberto G Lucchini; Denise Gaughan; Cheuk Y Tang; Megan K Horton Journal: Neurotoxicology Date: 2020-03-23 Impact factor: 4.398