Jori S Pesonen1,2, Robin W M Vernooij3, Rufus Cartwright4,5, Yoshitaka Aoki6, Arnav Agarwal7, Altaf Mangera8, Alayne D Markland9,10, Johnson F Tsui11, Henrikki Santti12, Tomas L Griebling13, Alexey E Pryalukhin14,15, Jarno Riikonen2, Riikka M Tähtinen16, Camille P Vaughan10,17, Theodore M Johnson10,17, Diane Heels-Ansdell18, Gordon H Guyatt19,18, Kari A O Tikkinen12,20. 1. Department of Urology, Päijät-Häme Central Hospital, Lahti, Finland. 2. Department of Urology, Tampere University Hospital, and Faculty of Medicine and Life Science, University of Tampere, Tampere, Finland. 3. Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands. 4. Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom. 5. Department of Urogynaecology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom. 6. Department of Urology, University of Fukui, Fukui, Japan. 7. Department of Medicine, University of Toronto, Toronto, Canada. 8. Department of Urology, Sheffield Teaching Hospitals, Sheffield, United Kingdom. 9. Department of Medicine, Division of Gerontology, Geriatrics and Palliative Care, University of Alabama-Birmingham UAB School of Medicine, Birmingham, Alabama. 10. Department of Veterans Affairs, Birmingham/Atlanta Geriatric Research Education and Clinical Center, Atlanta, Georgia. 11. Department of Urology, Hackensack University Medical Center, Hackensack, New Jersey. 12. Department of Urology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. 13. Department of Urology and The Landon Center On Aging, University of Kansas, Kansas City, Kansas. 14. Department of Urology, North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia. 15. Department of Pathology, University Hospital of Bonn, Bonn, Germany. 16. Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland. 17. Department of Medicine, Division of General Medicine and Geriatrics, Emory University School of Medicine, Atlanta, Georgia. 18. Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. 19. Department of Medicine, McMaster University, Hamilton, Ontario, Canada. 20. Department of Public Health, University of Helsinki, Helsinki, Finland.
Abstract
PURPOSE: Although nocturia is associated with various comorbidities, its impact on falls and fractures remains unclear. We performed a systematic review and meta-analysis to evaluate the association between nocturia and falls and fractures as a prognostic and as a causal risk factor. MATERIALS AND METHODS: We searched PubMed®, Scopus®, CINAHL (Cumulative Index to Nursing and Allied Health Literature) and abstracts of major urological meetings up to December 31, 2018. We conducted random effects meta-analyses of adjusted relative risks of falls and fractures. We applied the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to rate the quality of evidence for nocturia as a prognostic and causal factor of falls and fractures. RESULTS: Among 5,230 potential reports 9 observational longitudinal studies provided data on the association between nocturia and falls or fractures (1 for both, 4 for falls, 4 for fractures). Pooled estimates demonstrated a risk ratio of 1.20 (95% CI 1.05-1.37, I2=51.7%, annual risk difference 7.5% among the elderly) for association between nocturia and falls and 1.32 (95% CI 0.99-1.76, I2=57.5%, annual risk difference 1.2%) for association between nocturia and fractures. Subgroup analyses showed no significant effect modification by age, gender, followup time, nocturia case definition or risk of bias. We rated the quality of evidence for nocturia as a prognostic factor as moderate for falls and low for fractures, and as very low as a cause of falls/fractures. CONCLUSIONS: Nocturia is probably associated with an approximately 1.2-fold increased risk of falls and possibly an approximately 1.3-fold increased risk of fractures.
PURPOSE: Although nocturia is associated with various comorbidities, its impact on falls and fractures remains unclear. We performed a systematic review and meta-analysis to evaluate the association between nocturia and falls and fractures as a prognostic and as a causal risk factor. MATERIALS AND METHODS: We searched PubMed®, Scopus®, CINAHL (Cumulative Index to Nursing and Allied Health Literature) and abstracts of major urological meetings up to December 31, 2018. We conducted random effects meta-analyses of adjusted relative risks of falls and fractures. We applied the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to rate the quality of evidence for nocturia as a prognostic and causal factor of falls and fractures. RESULTS: Among 5,230 potential reports 9 observational longitudinal studies provided data on the association between nocturia and falls or fractures (1 for both, 4 for falls, 4 for fractures). Pooled estimates demonstrated a risk ratio of 1.20 (95% CI 1.05-1.37, I2=51.7%, annual risk difference 7.5% among the elderly) for association between nocturia and falls and 1.32 (95% CI 0.99-1.76, I2=57.5%, annual risk difference 1.2%) for association between nocturia and fractures. Subgroup analyses showed no significant effect modification by age, gender, followup time, nocturia case definition or risk of bias. We rated the quality of evidence for nocturia as a prognostic factor as moderate for falls and low for fractures, and as very low as a cause of falls/fractures. CONCLUSIONS:Nocturia is probably associated with an approximately 1.2-fold increased risk of falls and possibly an approximately 1.3-fold increased risk of fractures.
Authors: Kim Pauwaert; An-Sofie Goessaert; Lynn Ghijselings; Thomas F Monaghan; Herman Depypere; Karel Everaert Journal: Int Urogynecol J Date: 2021-01-13 Impact factor: 2.894
Authors: Manuel Montero-Odasso; Nathalie van der Velde; Finbarr C Martin; Mirko Petrovic; Maw Pin Tan; Jesper Ryg; Sara Aguilar-Navarro; Neil B Alexander; Clemens Becker; Hubert Blain; Robbie Bourke; Ian D Cameron; Richard Camicioli; Lindy Clemson; Jacqueline Close; Kim Delbaere; Leilei Duan; Gustavo Duque; Suzanne M Dyer; Ellen Freiberger; David A Ganz; Fernando Gómez; Jeffrey M Hausdorff; David B Hogan; Susan M W Hunter; Jose R Jauregui; Nellie Kamkar; Rose-Anne Kenny; Sarah E Lamb; Nancy K Latham; Lewis A Lipsitz; Teresa Liu-Ambrose; Pip Logan; Stephen R Lord; Louise Mallet; David Marsh; Koen Milisen; Rogelio Moctezuma-Gallegos; Meg E Morris; Alice Nieuwboer; Monica R Perracini; Frederico Pieruccini-Faria; Alison Pighills; Catherine Said; Ervin Sejdic; Catherine Sherrington; Dawn A Skelton; Sabestina Dsouza; Mark Speechley; Susan Stark; Chris Todd; Bruce R Troen; Tischa van der Cammen; Joe Verghese; Ellen Vlaeyen; Jennifer A Watt; Tahir Masud Journal: Age Ageing Date: 2022-09-02 Impact factor: 12.782
Authors: Scott R Bauer; Peggy M Cawthon; Kristine E Ensrud; Anne M Suskind; John C Newman; Howard A Fink; Kaiwei Lu; Rebecca Scherzer; Andrew R Hoffman; Kenneth Covinsky; Lynn M Marshall Journal: J Am Geriatr Soc Date: 2021-12-24 Impact factor: 5.562
Authors: Benjamin N Breyer; Scott R Bauer; Austin W Lee; Stacey A Kenfield; Elizabeth Y Wang; Anthony Enriquez; Akinyemi Oni-Orisan; Michael A Steinman; Ida Sim Journal: JMIR Form Res Date: 2021-12-10