Angela Ju1,2, Mark Unruh3, Sara N Davison4, Juan Dapueto5, Mary A Dew6, Richard Fluck7, Michael Germain8, Sarbjit V Jassal9, Gregorio Obrador10, Donal O'Donoghue11, Martin Howell1,2, Emma O'Lone1,2, Jenny I Shen12, Jonathan C Craig13, Allison Tong1,2. 1. Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia. 2. Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia. 3. Division of Nephrology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA. 4. Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. 5. Departamento de Psicología Médica, Hospital de Clínicas. Facultad de Medicina, Universidad de la República. Montevideo, Uruguay. 6. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. 7. Department of Renal Medicine, Royal Derby Hospital, Derby, UK. 8. Renal and Transplant Associates of New England, Division of Nephrology, Baystate Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA. 9. Division of Nephrology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada. 10. Universidad Panamericana School of Medicine, Mexico City, Mexico. 11. Department of Renal Medicine, Salford Royal Hospital, Salford, UK. 12. Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor-UCLA Medical Center, Torrance, California, USA. 13. College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Abstract
BACKGROUND: Patient-reported outcome measures of fatigue used in research in haemodialysis vary widely in the dimensions assessed; and the importance of these dimensions to patients and health professionals is unknown. This study aimed to identify the most important dimensions of fatigue to assess in patients on haemodialysis participating in trials. METHODS: In an international survey, patients/caregivers and health professionals rated the absolute and relative importance of content and measurement dimensions to include in a core outcome measure of fatigue. A 9-point Likert scale (7-9 indicating critical importance) was used to assess absolute importance and best-worst scale was used to assess importance of each dimension compared to others. RESULTS: In total, 169 patients/caregivers and 336 health professionals from 60 countries completed the survey. Both groups (patients/caregivers and health professionals) rated life participation (7.55), tiredness (7.40), level of energy (7.37), ability to think clearly (7.15), post-dialysis fatigue (7.13), motivation (7.03) and ability to concentrate (7.03) as critically important (mean Likert score greater than 7) content dimensions to include in a core outcome measure. Compared to patients and caregivers, health professionals rated post-dialysis fatigue, memory and verbal abilities more highly. Based on the relative importance scores, life participation was ranked most highly above all content dimensions. Severity was rated and ranked the most important measurement dimension by all stakeholders. CONCLUSION: A core outcome measure of fatigue should assess impact of fatigue on life participation, tiredness and level of energy, using a severity scale. A consistent and valid measurement of fatigue will improve the value of trials in supporting decision-making based on this important outcome.
BACKGROUND:Patient-reported outcome measures of fatigue used in research in haemodialysis vary widely in the dimensions assessed; and the importance of these dimensions to patients and health professionals is unknown. This study aimed to identify the most important dimensions of fatigue to assess in patients on haemodialysis participating in trials. METHODS: In an international survey, patients/caregivers and health professionals rated the absolute and relative importance of content and measurement dimensions to include in a core outcome measure of fatigue. A 9-point Likert scale (7-9 indicating critical importance) was used to assess absolute importance and best-worst scale was used to assess importance of each dimension compared to others. RESULTS: In total, 169 patients/caregivers and 336 health professionals from 60 countries completed the survey. Both groups (patients/caregivers and health professionals) rated life participation (7.55), tiredness (7.40), level of energy (7.37), ability to think clearly (7.15), post-dialysis fatigue (7.13), motivation (7.03) and ability to concentrate (7.03) as critically important (mean Likert score greater than 7) content dimensions to include in a core outcome measure. Compared to patients and caregivers, health professionals rated post-dialysis fatigue, memory and verbal abilities more highly. Based on the relative importance scores, life participation was ranked most highly above all content dimensions. Severity was rated and ranked the most important measurement dimension by all stakeholders. CONCLUSION: A core outcome measure of fatigue should assess impact of fatigue on life participation, tiredness and level of energy, using a severity scale. A consistent and valid measurement of fatigue will improve the value of trials in supporting decision-making based on this important outcome.
Authors: Angela Ju; Armando Teixeira-Pinto; Allison Tong; Alice C Smith; Mark Unruh; Sara N Davison; Juan Dapueto; Mary Amanda Dew; Richard Fluck; Michael J Germain; Sarbjit V Jassal; Gregorio T Obrador; Donal O'Donoghue; Andrea K Viecelli; Giovanni Strippoli; Marinella Ruospo; Delia Timofte; Ankit Sharma; Eric Au; Martin Howell; Daniel S J Costa; Samaya Anumudu; Jonathan C Craig; Claudia Rutherford Journal: Clin J Am Soc Nephrol Date: 2020-10-22 Impact factor: 8.237
Authors: Aminu K Bello; Ikechi G Okpechi; Mohamed A Osman; Yeoungjee Cho; Htay Htay; Vivekanand Jha; Marina Wainstein; David W Johnson Journal: Nat Rev Nephrol Date: 2022-02-22 Impact factor: 42.439