Literature DB >> 31346975

Identification of hepatitis B virus genotype A/E recombinants in Ghana.

Ceejay L Boyce1, Stephaney Willis1, Timothy N A Archampong2,3, Margaret Lartey2,3, Kwamena W Sagoe4, Adjoa Obo-Akwa2, Ernest Kenu3,5, Awewura Kwara6, Jason T Blackard7.   

Abstract

Hepatitis B virus (HBV) exhibits a high degree of heterogeneity with at least 10 genotypes (A-J) identified to date. Intergenotypic recombination is relatively common. Previously, we investigated HBV drug resistance in HIV/HBV co-infected individuals in Ghana. After identifying multiple circulating genotypes and a novel D/E recombinant, we sought to determine if additional individuals were also infected with recombinant HBV. Partial genome sequences from three individuals were initially identified as genotype A4. Full-length HBV genomes were obtained using rolling circle amplification followed by PCR and shown to cluster with known A/E recombinant viruses. Similar recombination breakpoints were observed in these three individuals suggesting local spread of this novel recombinant HBV in Ghana.

Entities:  

Keywords:  Africa; Genotype; Ghana; Hepatitis B virus; Recombinant/recombination

Mesh：

Year:  2019        PMID： 31346975      PMCID： PMC6750976          DOI： 10.1007/s11262-019-01690-y

Source DB:  PubMed          Journal:  Virus Genes        ISSN： 0920-8569            Impact factor:   2.332


  25 in total

Review 1.  Hepatitis B virus taxonomy and hepatitis B virus genotypes.

Authors:  Stephan Schaefer
Journal:  World J Gastroenterol       Date:  2007-01-07       Impact factor: 5.742

2.  A new subtype (subgenotype) Ac (A3) of hepatitis B virus and recombination between genotypes A and E in Cameroon.

Authors:  Fuat Kurbanov; Yasuhito Tanaka; Kei Fujiwara; Fuminaka Sugauchi; Dora Mbanya; Leopold Zekeng; Nicaise Ndembi; Charlotte Ngansop; Lazare Kaptue; Tomoyuki Miura; Eiji Ido; Masanori Hayami; Hiroshi Ichimura; Masashi Mizokami
Journal:  J Gen Virol       Date:  2005-07       Impact factor: 3.891

3.  Molecular analysis of hepatitis B virus genomes isolated from black African patients with fulminant hepatitis B.

Authors:  W K Owiredu; A Kramvis; M C Kew
Journal:  J Med Virol       Date:  2001-11       Impact factor: 2.327

4.  A novel hepatitis B virus (HBV) subgenotype D (D8) strain, resulting from recombination between genotypes D and E, is circulating in Niger along with HBV/E strains.

Authors:  Mariama Abdou Chekaraou; Ségolène Brichler; Waël Mansour; Frédéric Le Gal; Aminata Garba; Paul Dény; Emmanuel Gordien
Journal:  J Gen Virol       Date:  2010-02-10       Impact factor: 3.891

5.  Phylogenetic analysis of the precore/core gene of hepatitis B virus genotypes E and A in West Africa: new subtypes, mixed infections and recombinations.

Authors:  Christophe M Olinger; Véronique Venard; Mounjohou Njayou; Akeeb O Bola Oyefolu; Ibrahim Maïga; Alain J Kemp; Sunday A Omilabu; Alain le Faou; Claude P Muller
Journal:  J Gen Virol       Date:  2006-05       Impact factor: 3.891

6.  Identification of hepatitis B virus subgenotype A3 in rural Gabon.

Authors:  Maria Makuwa; Sandrine Souquière; Paul Telfer; Cristian Apetrei; Muriel Vray; Issa Bedjabaga; Augustin Mouinga-Ondeme; Richard Onanga; Preston A Marx; Mirdad Kazanji; Pierre Roques; François Simon
Journal:  J Med Virol       Date:  2006-09       Impact factor: 2.327

7.  Deletions and recombinations in the core region of hepatitis B virus genotype E strains from asymptomatic blood donors in Guinea, west Africa.

Authors:  Penelope Garmiri; André Loua; Nyankoye Haba; Daniel Candotti; Jean-Pierre Allain
Journal:  J Gen Virol       Date:  2009-06-17       Impact factor: 3.891

8.  A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J.

Authors:  Kanako Tatematsu; Yasuhito Tanaka; Fuat Kurbanov; Fuminaka Sugauchi; Shuhei Mano; Tatsuji Maeshiro; Tomokuni Nakayoshi; Moriaki Wakuta; Yuzo Miyakawa; Masashi Mizokami
Journal:  J Virol       Date:  2009-07-29       Impact factor: 5.103

9.  Central African Republic is part of the West-African hepatitis B virus genotype E crescent.

Authors:  Claudine Bekondi; Christophe M Olinger; Nathalie Boua; Antoine Talarmin; Claude P Muller; Alain Le Faou; Véronique Venard
Journal:  J Clin Virol       Date:  2007-08-03       Impact factor: 3.168

10.  Hepatitis B virus genotype G epidemiology and co-infection with genotype A in Canada.

Authors:  Carla Osiowy; Diane Gordon; Jamie Borlang; Elizabeth Giles; Jean-Pierre Villeneuve
Journal:  J Gen Virol       Date:  2008-12       Impact factor: 3.891
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