Anna Oliveras1,2, Albert Goday3,4, Laia Sans5, Carlos E Arias5, Susana Vazquez6,5, David Benaiges3, José Manuel Ramon7, Julio Pascual5. 1. Hypertension Unit, Nephrology Department, Hospital Universitari del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. aoliveras@hospitaldelmar.cat. 2. Nephrology Department, Hospital Universitari del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. aoliveras@hospitaldelmar.cat. 3. Endocrinology Department, Hospital Universitari del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. 4. Medicine Department, Universitat Autònoma de Barcelona, Centro de Investigaciones Biomédicas en Red de Obesidad y Nutrición, CIBERobn, Instituto de Salud Carlos III, Madrid, Spain. 5. Nephrology Department, Hospital Universitari del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. 6. Hypertension Unit, Nephrology Department, Hospital Universitari del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. 7. General Surgery Department, Hospital Universitari del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Abstract
BACKGROUND: Weight loss is associated to blood pressure (BP) reduction in obese patients. There is no information on central 24-h BP changes after bariatric surgery (BS). METHODS AND RESULTS: In this study, we analyzed changes in 24-h BP 12 months following BS, with intermediate evaluations at 1, 3, and 6 months, in severely obese adults. The primary endpoint was aortic (central) 24-h systolic BP changes. Circadian BP patterns and hypertension resolution were also assessed. As secondary endpoints, we analyze changes in central 24-h diastolic BP as well as in all office and ambulatory peripheral BP parameters. Obese adults scheduled for BS as routine clinical care were recruited. We included 62 patients (39% with hypertension, 77% women, body mass index, 42.6 ± 5.5 kg/m2). Reduction in body weight was mean (IQR) 30.5% (26.2-34.4) 1 year after BS. Mean (95% CI) change in central 24-h systolic BP was - 3.1 mmHg (- 5.5 to - 0.7), p = 0.01 after adjustment for age, sex, and baseline hypertensive status. BP parameter changes were different between normotensives and hypertensives. Mean (95% CI) change in central 24-h systolic BP was - 5.2 mmHg (- 7.7 to - 2.7), p < 0.001, in normotensives and - 0.5 mmHg (- 5.1 to 4.0), p = 0.818, in hypertensives. There was a remission of hypertension in 48% of patients. Most patients had a reduced dipping pattern, similarly at baseline and 12 months after BS. CONCLUSIONS: Among patients with severe obesity, there was a substantial central 24-h systolic BP decrease 12 months following BS. Importantly, this change was observed in those patients with normal BP at baseline. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03115502.
BACKGROUND:Weight loss is associated to blood pressure (BP) reduction in obesepatients. There is no information on central 24-h BP changes after bariatric surgery (BS). METHODS AND RESULTS: In this study, we analyzed changes in 24-h BP 12 months following BS, with intermediate evaluations at 1, 3, and 6 months, in severely obese adults. The primary endpoint was aortic (central) 24-h systolic BP changes. Circadian BP patterns and hypertension resolution were also assessed. As secondary endpoints, we analyze changes in central 24-h diastolic BP as well as in all office and ambulatory peripheral BP parameters. Obese adults scheduled for BS as routine clinical care were recruited. We included 62 patients (39% with hypertension, 77% women, body mass index, 42.6 ± 5.5 kg/m2). Reduction in body weight was mean (IQR) 30.5% (26.2-34.4) 1 year after BS. Mean (95% CI) change in central 24-h systolic BP was - 3.1 mmHg (- 5.5 to - 0.7), p = 0.01 after adjustment for age, sex, and baseline hypertensive status. BP parameter changes were different between normotensives and hypertensives. Mean (95% CI) change in central 24-h systolic BP was - 5.2 mmHg (- 7.7 to - 2.7), p < 0.001, in normotensives and - 0.5 mmHg (- 5.1 to 4.0), p = 0.818, in hypertensives. There was a remission of hypertension in 48% of patients. Most patients had a reduced dipping pattern, similarly at baseline and 12 months after BS. CONCLUSIONS: Among patients with severe obesity, there was a substantial central 24-h systolic BP decrease 12 months following BS. Importantly, this change was observed in those patients with normal BP at baseline. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03115502.
Authors: Anastasios Kollias; Styliani Lagou; Maria Elena Zeniodi; Nadia Boubouchairopoulou; George S Stergiou Journal: Hypertension Date: 2015-11-23 Impact factor: 10.190
Authors: Eoin O'Brien; Gianfranco Parati; George Stergiou; Roland Asmar; Laurie Beilin; Grzegorz Bilo; Denis Clement; Alejandro de la Sierra; Peter de Leeuw; Eamon Dolan; Robert Fagard; John Graves; Geoffrey A Head; Yutaka Imai; Kazuomi Kario; Empar Lurbe; Jean-Michel Mallion; Giuseppe Mancia; Thomas Mengden; Martin Myers; Gbenga Ogedegbe; Takayoshi Ohkubo; Stefano Omboni; Paolo Palatini; Josep Redon; Luis M Ruilope; Andrew Shennan; Jan A Staessen; Gert vanMontfrans; Paolo Verdecchia; Bernard Waeber; Jiguang Wang; Alberto Zanchetti; Yuqing Zhang Journal: J Hypertens Date: 2013-09 Impact factor: 4.844
Authors: Bryan Williams; Peter S Lacy; Simon M Thom; Kennedy Cruickshank; Alice Stanton; David Collier; Alun D Hughes; H Thurston; Michael O'Rourke Journal: Circulation Date: 2006-02-13 Impact factor: 29.690
Authors: Ted D Adams; Lance E Davidson; Sheldon E Litwin; Ronette L Kolotkin; Michael J LaMonte; Robert C Pendleton; Michael B Strong; Russell Vinik; Nathan A Wanner; Paul N Hopkins; Richard E Gress; James M Walker; Tom V Cloward; R Tom Nuttall; Ahmad Hammoud; Jessica L J Greenwood; Ross D Crosby; Rodrick McKinlay; Steven C Simper; Sherman C Smith; Steven C Hunt Journal: JAMA Date: 2012-09-19 Impact factor: 56.272
Authors: Peter M van Brussel; Bas van den Bogaard; Barbara A de Weijer; Jasper Truijen; C T Paul Krediet; Ignace M Janssen; Arnold van de Laar; Karin Kaasjager; Eric Fliers; Johannes J van Lieshout; Mireille J Serlie; Bert-Jan H van den Born Journal: J Appl Physiol (1985) Date: 2016-10-20
Authors: Robert M Weisbrod; Tina Shiang; Leona Al Sayah; Jessica L Fry; Saumendra Bajpai; Cynthia A Reinhart-King; Heinrich E Lob; Lakshmi Santhanam; Gary Mitchell; Richard A Cohen; Francesca Seta Journal: Hypertension Date: 2013-09-23 Impact factor: 10.190
Authors: Michelle M Harbin; Neil E Hultgren; Aaron S Kelly; Donald R Dengel; Nicholas G Evanoff; Justin R Ryder Journal: Am J Hypertens Date: 2018-11-13 Impact factor: 2.689
Authors: Peter Hallersund; Lars Sjöström; Torsten Olbers; Hans Lönroth; Peter Jacobson; Ville Wallenius; Ingmar Näslund; Lena M Carlsson; Lars Fändriks Journal: PLoS One Date: 2012-11-29 Impact factor: 3.240
Authors: Anna Oliveras; Lluís Molina; Albert Goday; Laia Sans; Marta Riera; Susana Vazquez; David Benaiges; Ana Marina Granados; José Manuel Ramon; Julio Pascual Journal: J Clin Hypertens (Greenwich) Date: 2020-12-17 Impact factor: 3.738
Authors: Anna Oliveras; Isabel Galceran; Albert Goday; Susana Vázquez; Laia Sans; Marta Riera; David Benaiges; Julio Pascual Journal: J Clin Med Date: 2021-02-10 Impact factor: 4.241
Authors: Anna Oliveras; Susana Vázquez; María José Soler; Isabel Galceran; Xavier Duran; Albert Goday; David Benaiges; Marta Crespo; Julio Pascual; Marta Riera Journal: J Clin Med Date: 2022-01-29 Impact factor: 4.241