| Literature DB >> 3134625 |
H Suzuki1, M Takeda, Y Nakamura, Y Kato, K Tada, S Hariguchi, T Nishimura.
Abstract
The effect of cathepsin D on bovine neurofilament protein was studied biochemically, immunologically, and morphologically. Degradation products of each neurofilament triplet by bovine brain cathepsin D at neutral pH were identified by electrophoresis and immunoblotting with anti-neurofilament antibodies. The 68-kDa subunit was the most susceptive to cathepsin D proteolysis among the triplet proteins. All of the triplet gave rise to partial degradates of the 50-kDa size. The reconstituted fiber from neurofilament triplet proteins and the 68-kDa subunit protein were attacked by cathepsin D and the mode of disruption of the fiber structure was studied by electronmicroscopy.Entities:
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Year: 1988 PMID： 3134625 DOI： 10.1016/0304-3940(88)90388-6
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046