William Gansheng Shi1, Mark Crowther2. 1. Michael G. DeGroote School of Medicine, McMaster University, 1280 Main Street West, ON L8P 1H6, Hamilton, Canada. Electronic address: william.shi@medportal.ca. 2. Michael G. DeGroote School of Medicine, McMaster University, 1280 Main Street West, ON L8P 1H6, Hamilton, Canada. Electronic address: crowthrm@mcmaster.ca.