Targeting Arterial Oxygen Saturation by Closed-Loop Control of Inspired Oxygen in Preterm Infants.

Exposure to hyperoxemia from excessive oxygen supplementation and episodes of intermittent hypoxemia have been associated with damage to the eye, lung, and central nervous system in premature infants. The inherent respiratory instability of the premature infant combined with limited staffing or equipment resources often affect SpO2 targeting and increase exposure to extreme SpO2 levels. Multiple systems for closed loop control of inspired oxygen have been developed to improve SpO2 targeting. This article reviews the evidence provided by clinical studies evaluating the efficacy of these systems in extreme premature infants.