Sierra E Carter1, Mei Ling Ong2, Ronald L Simons3, Frederick X Gibbons4, Man Kit Lei5, Steven R H Beach6. 1. Department of Psychology, Georgia State University. 2. Department of Education Psychology, University of Georgia. 3. Department of Sociology, University of Georgia. 4. Department of Psychology, University of Connecticut. 5. Center for Family Research, University of Georgia. 6. Department of Psychology, University of Georgia.
Abstract
OBJECTIVE: This study examined the role of depressive symptoms in mediating the relationship between early life experiences of racial discrimination and accelerated aging in adulthood for African Americans (i.e., prediction over a 19-year period, from ages 10 to 29) after adjusting for gender and health behaviors. METHOD: Longitudinal self-report data over 7 waves of data collection from the Family and Community Health Study were utilized. The sample included 368 African Americans with usable gene expression data to compute accelerated aging, as well as complete data on all self-report variables including racial discrimination (Schedule of Racist Events) and depression (Diagnostic Interview Schedule for Children-Version 4). Blood was collected by antecubital blood draws from participants at age 29. The proposed model was tested by path analysis. RESULTS: Findings revealed that high discrimination at ages 10-15 was associated with depression at ages 20-29 (β = .19, p = .001), controlling for depression at ages 10-15, which, in turn, was related to accelerated cellular-level aging (β = .11, p = .048) after controlling for gender, alcohol consumption, and cigarette use. The indirect effect of racial discrimination on aging through depression at ages 20-29 was significant (β = .021, 95% confidence interval [.001, .057]), accounting for 32.3% of the total variance. CONCLUSION: These findings support research conceptualizations that early life stress due to racial discrimination lead to sustained negative affective states continuing into young adulthood that confer risk for accelerated aging and possibly premature disease and mortality in African Americans. These findings advance knowledge of potential underlying mechanisms that influence racial health disparities. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
OBJECTIVE: This study examined the role of depressive symptoms in mediating the relationship between early life experiences of racial discrimination and accelerated aging in adulthood for African Americans (i.e., prediction over a 19-year period, from ages 10 to 29) after adjusting for gender and health behaviors. METHOD: Longitudinal self-report data over 7 waves of data collection from the Family and Community Health Study were utilized. The sample included 368 African Americans with usable gene expression data to compute accelerated aging, as well as complete data on all self-report variables including racial discrimination (Schedule of Racist Events) and depression (Diagnostic Interview Schedule for Children-Version 4). Blood was collected by antecubital blood draws from participants at age 29. The proposed model was tested by path analysis. RESULTS: Findings revealed that high discrimination at ages 10-15 was associated with depression at ages 20-29 (β = .19, p = .001), controlling for depression at ages 10-15, which, in turn, was related to accelerated cellular-level aging (β = .11, p = .048) after controlling for gender, alcohol consumption, and cigarette use. The indirect effect of racial discrimination on aging through depression at ages 20-29 was significant (β = .021, 95% confidence interval [.001, .057]), accounting for 32.3% of the total variance. CONCLUSION: These findings support research conceptualizations that early life stress due to racial discrimination lead to sustained negative affective states continuing into young adulthood that confer risk for accelerated aging and possibly premature disease and mortality in African Americans. These findings advance knowledge of potential underlying mechanisms that influence racial health disparities. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Authors: Laura K M Han; Moji Aghajani; Shaunna L Clark; Robin F Chan; Mohammad W Hattab; Andrey A Shabalin; Min Zhao; Gaurav Kumar; Lin Ying Xie; Rick Jansen; Yuri Milaneschi; Brian Dean; Karolina A Aberg; Edwin J C G van den Oord; Brenda W J H Penninx Journal: Am J Psychiatry Date: 2018-04-16 Impact factor: 18.112
Authors: Frederick X Gibbons; John H Kingsbury; Chih-Yuan Weng; Meg Gerrard; Carolyn Cutrona; Thomas A Wills; Michelle Stock Journal: Health Psychol Date: 2014-01 Impact factor: 4.267
Authors: Marjolein J Peters; Roby Joehanes; Luke C Pilling; Claudia Schurmann; Karen N Conneely; Joseph Powell; Eva Reinmaa; George L Sutphin; Alexandra Zhernakova; Katharina Schramm; Yana A Wilson; Sayuko Kobes; Taru Tukiainen; Yolande F Ramos; Harald H H Göring; Myriam Fornage; Yongmei Liu; Sina A Gharib; Barbara E Stranger; Philip L De Jager; Abraham Aviv; Daniel Levy; Joanne M Murabito; Peter J Munson; Tianxiao Huan; Albert Hofman; André G Uitterlinden; Fernando Rivadeneira; Jeroen van Rooij; Lisette Stolk; Linda Broer; Michael M P J Verbiest; Mila Jhamai; Pascal Arp; Andres Metspalu; Liina Tserel; Lili Milani; Nilesh J Samani; Pärt Peterson; Silva Kasela; Veryan Codd; Annette Peters; Cavin K Ward-Caviness; Christian Herder; Melanie Waldenberger; Michael Roden; Paula Singmann; Sonja Zeilinger; Thomas Illig; Georg Homuth; Hans-Jörgen Grabe; Henry Völzke; Leif Steil; Thomas Kocher; Anna Murray; David Melzer; Hanieh Yaghootkar; Stefania Bandinelli; Eric K Moses; Jack W Kent; Joanne E Curran; Matthew P Johnson; Sarah Williams-Blangero; Harm-Jan Westra; Allan F McRae; Jennifer A Smith; Sharon L R Kardia; Iiris Hovatta; Markus Perola; Samuli Ripatti; Veikko Salomaa; Anjali K Henders; Nicholas G Martin; Alicia K Smith; Divya Mehta; Elisabeth B Binder; K Maria Nylocks; Elizabeth M Kennedy; Torsten Klengel; Jingzhong Ding; Astrid M Suchy-Dicey; Daniel A Enquobahrie; Jennifer Brody; Jerome I Rotter; Yii-Der I Chen; Jeanine Houwing-Duistermaat; Margreet Kloppenburg; P Eline Slagboom; Quinta Helmer; Wouter den Hollander; Shannon Bean; Towfique Raj; Noman Bakhshi; Qiao Ping Wang; Lisa J Oyston; Bruce M Psaty; Russell P Tracy; Grant W Montgomery; Stephen T Turner; John Blangero; Ingrid Meulenbelt; Kerry J Ressler; Jian Yang; Lude Franke; Johannes Kettunen; Peter M Visscher; G Gregory Neely; Ron Korstanje; Robert L Hanson; Holger Prokisch; Luigi Ferrucci; Tonu Esko; Alexander Teumer; Joyce B J van Meurs; Andrew D Johnson Journal: Nat Commun Date: 2015-10-22 Impact factor: 14.919
Authors: Brooke G McKenna; Yara Mekawi; Seyma Katrinli; Sierra Carter; Jennifer S Stevens; Abigail Powers; Alicia K Smith; Vasiliki Michopoulos Journal: Psychosom Med Date: 2021 Nov-Dec 01 Impact factor: 4.312
Authors: Stirling T Argabright; Tyler M Moore; Elina Visoki; Grace E DiDomenico; Jerome H Taylor; Ran Barzilay Journal: Psychoneuroendocrinology Date: 2022-03-15 Impact factor: 4.693
Authors: Stephanie Shiau; Sean S Brummel; Elizabeth M Kennedy; Karen Hermetz; Stephen A Spector; Paige L Williams; Deborah Kacanek; Renee Smith; Stacy S Drury; Allison Agwu; Angela Ellis; Kunjal Patel; George R Seage; Russell B Van Dyke; Carmen J Marsit Journal: AIDS Date: 2021-04-01 Impact factor: 4.632