| Literature DB >> 3134293 |
J F Brunet1, F Denizot, P Golstein.
Abstract
One approach to the isolation of molecules involved in T cell-mediated cytolysis stems from the postulate of a possible correlation between molecular phenotype and molecular functional involvement. Accordingly, CTL-specific molecules have been looked for, using a strategy based on the differential screening of a subtracted cDNA library. This led to the isolation and characterization of the following structures, expressed mostly (but no exclusively) in CTLs and inducible upon lymphocyte activation: CTLA-1 and CTLA-3 (serine-proteases), CTLA-4 (a member of the Ig superfamily) and CTLA-2 alpha and beta (homologues to the proregion of cysteine-proteases). The theoretical and practical limitations and the prospects of this type of approach are discussed.Entities:
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Year: 1988 PMID： 3134293 DOI： 10.1111/j.1600-065x.1988.tb00747.x
Source DB: PubMed Journal: Immunol Rev ISSN： 0105-2896 Impact factor: 12.988