Literature DB >> 31340944

Revealing a rare inflammatory oral manifestation in a 6-year-old child.

Samapika Routray1, Amit Kumar Adhya2, Joseph John3, Punit Dikhit1.   

Abstract

A 6-year-old child with an episodic history of ulcerations over buccal mucosa was found to have severe inflammation on the palatal aspect of permanent first molars with grade 2 mobility bilaterally. Radiographical features were suggestive of bone loss around permanent molars extending to the distal aspect of the deciduous first molars. The clinical and radiographical findings were indicative of periodontal degeneration without any apparent cause visible intraorally. Further biopsy was done from the rashes present on the malar prominences, which showed nodular aggregates of atypical cells in superficial dermis. These large histiocytic cells with vesicular nuclei and nuclear grooves were immunopositive for CD1a and S100, concluding the diagnosis of Langerhans cell histiocytosis. For treatment, patient was referred to Department of Haemato-oncology and chemotherapy was suggested as per protocol. © BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  dentistry and oral medicine; malignant disease and immunosuppression; paediatrics; pathology

Mesh:

Year:  2019        PMID: 31340944      PMCID: PMC6663152          DOI: 10.1136/bcr-2019-229483

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  15 in total

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Authors:  Carl E Allen; Miriam Merad; Kenneth L McClain
Journal:  N Engl J Med       Date:  2018-08-30       Impact factor: 91.245

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Authors:  J C Jones; G E Lilly; R H Marlette
Journal:  J Oral Surg       Date:  1970-06

3.  Treatment of Langerhans cell histiocytosis with a modified risk-adapted protocol-experience from a tertiary cancer institute in India.

Authors:  Gaurav Narula; Nirmalaya D Pradhan; Brijesh Arora; Sripad D Banavali
Journal:  Pediatr Blood Cancer       Date:  2018-03-07       Impact factor: 3.167

4.  Treating Langerhans cell histiocytosis, globally.

Authors:  Stephan Ladisch
Journal:  Pediatr Blood Cancer       Date:  2018-04-25       Impact factor: 3.167

5.  BRAFV600E and MAP2K1 mutations in Langerhans cell histiocytosis occur predominantly in children.

Authors:  Kaixuan Zeng; Koichi Ohshima; Yixiong Liu; Weichen Zhang; Lu Wang; Linni Fan; Mingyang Li; Xia Li; Zhe Wang; Shuangping Guo; Qingguo Yan; Ying Guo
Journal:  Hematol Oncol       Date:  2016-09-06       Impact factor: 5.271

6.  Novel activating BRAF fusion identifies a recurrent alternative mechanism for ERK activation in pediatric Langerhans cell histiocytosis.

Authors:  Sara Zarnegar; Benjamin H Durham; Pallavi Khattar; Neerav N Shukla; Ryma Benayed; Mario E Lacouture; Ehud Lavi; David C Lyden; Eli L Diamond; Ira J Dunkel; Omar Abdel-Wahab
Journal:  Pediatr Blood Cancer       Date:  2017-07-27       Impact factor: 3.167

7.  Pediatric histiocytosis. Characterization, prognosis, and oral involvement.

Authors:  D Filocoma; H L Needleman; R Arceci; R D Gelber; M Donnelly
Journal:  Am J Pediatr Hematol Oncol       Date:  1993-05

8.  Langerhans cell histiocytosis in a child: a 10-year follow-up.

Authors:  Paulo de Camargo Moraes; Marcelo Bönecker; Cristiane Furuse; Rubens Gonçalves Teixeira; Vera Cavalcanti Araujo
Journal:  Int J Paediatr Dent       Date:  2007-05       Impact factor: 3.455

9.  Oral Langerhans Cell Histiocytosis in an Infant.

Authors:  Elinor Halperson; Michael Weintraub
Journal:  J Dent Child (Chic)       Date:  2018-05-15

10.  Langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report.

Authors:  Angela Pia Cazzolla; Giuseppe Troiano; Khrystyna Zhurakivska; Eugenio Maiorano; Gianfranco Favia; Maria Grazia Lacaita; Giuseppe Marzo; Franca Dicuonzo; Stefano Andresciani; Lorenzo Lo Muzio
Journal:  J Med Case Rep       Date:  2017-05-09
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