| Literature DB >> 31340944 |
Samapika Routray1, Amit Kumar Adhya2, Joseph John3, Punit Dikhit1.
Abstract
A 6-year-old child with an episodic history of ulcerations over buccal mucosa was found to have severe inflammation on the palatal aspect of permanent first molars with grade 2 mobility bilaterally. Radiographical features were suggestive of bone loss around permanent molars extending to the distal aspect of the deciduous first molars. The clinical and radiographical findings were indicative of periodontal degeneration without any apparent cause visible intraorally. Further biopsy was done from the rashes present on the malar prominences, which showed nodular aggregates of atypical cells in superficial dermis. These large histiocytic cells with vesicular nuclei and nuclear grooves were immunopositive for CD1a and S100, concluding the diagnosis of Langerhans cell histiocytosis. For treatment, patient was referred to Department of Haemato-oncology and chemotherapy was suggested as per protocol. © BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.Entities:
Keywords: dentistry and oral medicine; malignant disease and immunosuppression; paediatrics; pathology
Mesh:
Year: 2019 PMID: 31340944 PMCID: PMC6663152 DOI: 10.1136/bcr-2019-229483
Source DB: PubMed Journal: BMJ Case Rep ISSN: 1757-790X