Literature DB >> 3134073

A possible role for prostaglandins in the expression of morphine dependence in guinea-pig isolated ileum.

M A Johnson1, R G Hill, J Hughes.   

Abstract

1. The effects of the cyclo-oxygenase inhibitors, indomethacin (1.3 microM) and mefenamic acid (10 microM), were investigated on the naloxone-precipitated withdrawal contracture of the morphine-dependent guinea-pig ileum in vitro. 2. Both indomethacin and mefenamic acid prevented expression of the withdrawal contracture on naloxone challenge. 3. The effects of indomethacin were reversed by the concurrent application of a low dose of prostaglandin E1 (10 nM). 4. It was concluded that prostaglandins probably play a role in the expression of morphine withdrawal in this model.

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Year:  1988        PMID： 3134073      PMCID： PMC1853880          DOI： 10.1111/j.1476-5381.1988.tb11482.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells.

Authors:  D Piomelli; A Volterra; N Dale; S A Siegelbaum; E R Kandel; J H Schwartz; F Belardetti
Journal:  Nature       Date:  1987 Jul 2-8       Impact factor: 49.962

2.  Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate.

Authors:  H O Collier; A C Roy
Journal:  Nature       Date:  1974-03-01       Impact factor: 49.962

3.  Prostaglandins reverse inhibition of electrically-induced contractions of guinea pig ileum by morphine, indomethacin and acetylsalicylic acid.

Authors:  S Ehrenpreis; J Greenberg; S Belman
Journal:  Nat New Biol       Date:  1973-10-31

4.  Manifestations of gut opiate withdrawal contracture and its blockade by capsaicin.

Authors:  K Tsou; G Louie; E L Way
Journal:  Eur J Pharmacol       Date:  1982-07-16       Impact factor: 4.432

5.  Cyclo-oxygenase inhibitors antagonize indirectly evoked contractions of the guinea-pig isolated ileum by inhibiting acetylcholine release.

Authors:  D T Okpako; Y O Taiwo
Journal:  Br J Pharmacol       Date:  1984-07       Impact factor: 8.739

6.  Contracture of guinea-pig ileum on withdrawal of methionine5-enkephalin is mediated by substance P.

Authors:  L A Chahl
Journal:  Br J Pharmacol       Date:  1983-12       Impact factor: 8.739

7.  Model of opiate dependence in the guinea-pig isolated ileum.

Authors:  H O Collier; N J Cuthbert; D L Francis
Journal:  Br J Pharmacol       Date:  1981-08       Impact factor: 8.739

8.  Inhibition by indomethacin of naloxone-precipitated opiate withdrawal contraction in isolated guinea pig myenteric plexus-longitudinal muscle preparation.

Authors:  M S Krakow; E D Ehrenpreis; S Ehrenpreis
Journal:  Life Sci       Date:  1986-07-21       Impact factor: 5.037

9.  A modulating role of prostaglandins in contractions of the guinea-pig ileum.

Authors:  O Kadlec; K Masek; I Seferna
Journal:  Br J Pharmacol       Date:  1974-08       Impact factor: 8.739
  9 in total
  1 in total

1.  Interactions between cholecystokinin and opioids in the isolated guinea-pig ileum.

Authors:  L Romanelli; M C Amico; F Mattioli; L A Morrone; P Valeri
Journal:  Br J Pharmacol       Date:  1999-06       Impact factor: 8.739
  1 in total

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