Yongjun Zhang1, Tao Yang1, Wenjiao Zhou1, Yuee Huang2. 1. Department of Electrocardiograph, Yijishan Hospital of Wannan Medical College, Wuhu 241001, China. 2. School of Public Health, Wannan Medical College, Wuhu 241002, China.
Abstract
OBJECTIVE: To investigate the association between genotype insertion or deletion polymorphism of the angiotensin-converting enzyme gene (ACE) and susceptibility to coronary artery disease (CAD) in Chinese Han population. METHODS: We conducted a comprehensive search for the OR value of contrast between the group of genotype insertion or deletion polymorphism of the ACE and the group of CAD as an effective index. A meta-analysis (Stata 12.0) was used to test the heterogeneity of the results, combine the values for effect, conduct sensitivity analysis, and basic evaluation. RESULTS: A total of 638 studies were found on the association between polymorphisms of the angiotensin-converting enzyme gene and CAD, of which 44 studies met the inclusion criteria. In total, our study included 5619 cases and 4865 controls. The heterogeneity test of each study (P < 0.001) was carried out using a random effect model. The OR value of DD/ID+II was 1.95, 95% confidence interval (95%CI) (1.66-2.29). The OR value of II/DI+DD was 0.63, 95%CI (0.55-0.72). The funnel figure is basically symmetrical and the results of the sensitivity analysis were stable. CONCLUSION: The DD genotype of the angiotensin converting enzyme gene may be a weaker risk factor for CAD in the Chinese Han population.
OBJECTIVE: To investigate the association between genotype insertion or deletion polymorphism of the angiotensin-converting enzyme gene (ACE) and susceptibility to coronary artery disease (CAD) in Chinese Han population. METHODS: We conducted a comprehensive search for the OR value of contrast between the group of genotype insertion or deletion polymorphism of the ACE and the group of CAD as an effective index. A meta-analysis (Stata 12.0) was used to test the heterogeneity of the results, combine the values for effect, conduct sensitivity analysis, and basic evaluation. RESULTS: A total of 638 studies were found on the association between polymorphisms of the angiotensin-converting enzyme gene and CAD, of which 44 studies met the inclusion criteria. In total, our study included 5619 cases and 4865 controls. The heterogeneity test of each study (P < 0.001) was carried out using a random effect model. The OR value of DD/ID+II was 1.95, 95% confidence interval (95%CI) (1.66-2.29). The OR value of II/DI+DD was 0.63, 95%CI (0.55-0.72). The funnel figure is basically symmetrical and the results of the sensitivity analysis were stable. CONCLUSION: The DD genotype of the angiotensin converting enzyme gene may be a weaker risk factor for CAD in the Chinese Han population.
Authors: Aadil Yousif; Rashid Mir; Jamsheed Javid; Jameel Barnawi; Mohammed M Jalal; Malik A Altayar; Salem Owaid Albalawi; Faisel M Abuduhier Journal: Diagnostics (Basel) Date: 2022-05-26
Authors: Alexandra Maștaleru; Sabina Alexandra Cojocariu; Andra Oancea; Maria Magdalena Leon Constantin; Mihai Roca; Ioana Mădălina Zota; Irina Abdulan; Cristina Rusu; Roxana Popescu; Lucian Mihai Antoci; Cristian Gabriel Ciobanu; Alexandru Dan Costache; Elena Cojocaru; Florin Mitu Journal: J Pers Med Date: 2022-03-09