Ole K L Helgestad1,2, Jakob Josiassen3, Christian Hassager3,4, Lisette O Jensen1, Lene Holmvang3,4, Anne Sørensen1, Martin Frydland3,4, Annmarie T Lassen5, Nanna L J Udesen1, Henrik Schmidt6, Hanne B Ravn4,7, Jacob E Møller1,2. 1. Department of Cardiology, Odense University Hospital, Odense, Denmark. 2. Odense Patient Data Explorative Network, University of Southern Denmark, Odense, Denmark. 3. Department of Cardiology, Rigshospitalet, Copenhagen, Denmark. 4. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. 5. Department of Emergency Medicine, Odense University Hospital, Odense, Denmark. 6. Department of Cardiothoracic Anaesthesia, Odense University Hospital, Odense, Denmark. 7. Department of Cardiac Anaesthesiology, Rigshospitalet, Copenhagen, Denmark.
Abstract
AIM: We sought to describe the contemporary annual incidence of cardiogenic shock (CS) following acute myocardial infarction (AMICS), the proportion of patients developing CS following ST-elevation myocardial infarction (STEMI), and other temporal changes in AMICS in Denmark between 2010 and 2017. METHODS AND RESULTS: Medical records of patients suspected of having AMICS during 2010-2017 were reviewed to identify consecutive patients with AMICS in a cohort corresponding to two-thirds of the Danish population. Due to changes in recruitment area over the study period, population-based incidence could only be calculated from 2012 to 2017. A total of 1716 patients with AMICS were identified and an increase in the annual incidence was observed, from a nadir 65.3 per million person-years in 2013 to 80.0 per million person-years in 2017 (P-value for trend < 0.001). This trend corresponded to an increase in patients with non-STEMI and a decrease in patients developing CS after STEMI (10.0-6.6%, P-value for trend < 0.001) Also, mean arterial blood pressure at the time of AMICS was lower (63 ± 11 mmHg to 61 ± 13 mmHg, P-value for trend = 0.001) and the frequency of patients with left ventricular ejection fraction ≤ 30% increased (61.8%-71.4%, P-value for trend = 0.004). The annual 30-day mortality during the study period remained unchanged at about 50%. CONCLUSION: The incidence rate of AMICS increased in the Danish population between 2012 and 2017. Fewer patients with STEMI developed CS, and haemodynamic severity of CS increased during the study period; however, survival rates remained unchanged.
AIM: We sought to describe the contemporary annual incidence of cardiogenic shock (CS) following acute myocardial infarction (AMICS), the proportion of patients developing CS following ST-elevation myocardial infarction (STEMI), and other temporal changes in AMICS in Denmark between 2010 and 2017. METHODS AND RESULTS: Medical records of patients suspected of having AMICS during 2010-2017 were reviewed to identify consecutive patients with AMICS in a cohort corresponding to two-thirds of the Danish population. Due to changes in recruitment area over the study period, population-based incidence could only be calculated from 2012 to 2017. A total of 1716 patients with AMICS were identified and an increase in the annual incidence was observed, from a nadir 65.3 per million person-years in 2013 to 80.0 per million person-years in 2017 (P-value for trend < 0.001). This trend corresponded to an increase in patients with non-STEMI and a decrease in patients developing CS after STEMI (10.0-6.6%, P-value for trend < 0.001) Also, mean arterial blood pressure at the time of AMICS was lower (63 ± 11 mmHg to 61 ± 13 mmHg, P-value for trend = 0.001) and the frequency of patients with left ventricular ejection fraction ≤ 30% increased (61.8%-71.4%, P-value for trend = 0.004). The annual 30-day mortality during the study period remained unchanged at about 50%. CONCLUSION: The incidence rate of AMICS increased in the Danish population between 2012 and 2017. Fewer patients with STEMI developed CS, and haemodynamic severity of CS increased during the study period; however, survival rates remained unchanged.
Authors: Cosme García-García; Teresa Oliveras; Nabil El Ouaddi; Ferran Rueda; Jordi Serra; Carlos Labata; Marc Ferrer; German Cediel; Santiago Montero; Maria Jose Martínez; Helena Resta; Oriol de Diego; Joan Vila; Irene R Dégano; Roberto Elosua; Josep Lupón; Antoni Bayes-Genis Journal: J Clin Med Date: 2020-07-27 Impact factor: 4.241
Authors: M D Lauridsen; J H Butt; L Østergaard; J E Møller; C Hassager; T Gerds; K Kragholm; M Phelps; M Schou; C Torp-Pedersen; G Gislason; L Køber; E L Fosbøl Journal: Int J Cardiol Heart Vasc Date: 2020-10-13
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Authors: Ole Kristian Lerche Helgestad; Jakob Josiassen; Christian Hassager; Lisette Okkels Jensen; Lene Holmvang; Nanna Louise Junker Udesen; Henrik Schmidt; Hanne Berg Ravn; Jacob Eifer Moller Journal: Open Heart Date: 2020-03-04
Authors: Héctor González-Pacheco; Amada Álvarez-Sangabriel; Carlos Martínez-Sánchez; José L Briseño-Cruz; Alfredo Altamirano-Castillo; Salvador Mendoza-García; Daniel Manzur-Sandoval; Luis M Amezcua-Guerra; Julio Sandoval; Rafael Bojalil; Diego Araiza-Garaygordobil; Daniel Sierra-Lara; Carlos A Guiza-Sánchez; Rodrigo Gopar-Nieto; Camelia Cruz-Rodríguez; José J Valdivia-Nuño; Brandon Salas-Teles; Alexandra Arias-Mendoza Journal: ESC Heart Fail Date: 2020-11-11