Sang Hwan Lee1, Jin Ho Hwang2, Dong Hyun Kim3, Young Ho So3, Jihong Park4, Soo Buem Cho5, Jeong-Eun Kim6, Young Jae Kim7, Saebeom Hur8, Hwan Jun Jae8. 1. Department of Radiology, H Plus Yangji Hospital, 1636, Nambusunhwan-ro, Gwanakgu, Seoul, Republic of Korea. major211@gmail.com. 2. Department of Radiology, Konkuk University School of Medicine, Seoul, Republic of Korea. 3. Department of Radiology, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Republic of Korea. 4. Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Bundang, Gyeonggi-do, Republic of Korea. 5. Department of Radiology, Ewha Womans University Seoul Hospital, Ewha Womans University, College of Medicine, Seoul, Republic of Korea. 6. Department of Radiology, Hallym University Sacred Heart Hospital, Pyeongchon, Gyeonggi-do, Republic of Korea. 7. Department of Biomedical Engineering, Gachon University College of Medicine, Incheon, Republic of Korea. 8. Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea.
Abstract
PURPOSE: This retrospective study was conducted to compare the clinical outcomes of transcatheter arterial embolisation for chronic knee pain in patients with mild-to-moderate versus severe knee osteoarthritis. MATERIALS AND METHODS: This study included patients (n = 41) who were refractory to conservative treatments and who underwent transcatheter arterial embolisation using imipenem/cilastatin sodium between June 2017 and July 2018. A total of 71 knees, including 30 bilateral cases, were treated and categorised into two groups according to the Kellgren-Lawrence grade: mild-to-moderate osteoarthritis (n = 59, Kellgren-Lawrence grade 1-3) and severe osteoarthritis (n = 12, Kellgren-Lawrence grade 4). The clinical outcomes were measured by the visual analogue scale score. RESULTS: There were no significant differences in age, body mass index or baseline visual analogue scale scores between the two groups. The mean visual analogue scale scores in the mild-to-moderate osteoarthritis group were significantly decreased at 1 day, 1 week, 1 month, 3 months, and 6-months (5.5 at baseline vs. 3.2, 3.1, 2.9, 2.2, and 1.9, after treatment; all P = .00). These improvements were maintained at a mean of 10 ± 3 months (range 6-19 months) post-treatment. The visual analogue scale scores were significantly decreased in the severe osteoarthritis group for 1 month post-treatment (6.3 at baseline vs. 4.1, 4.1, and 4.4 at 1 day, 1 week, and 1 month; all P < .01). However, a decrease in pain was not statistically significant from 3 to 6 months (5.4 and 5.9 at 3 months and 6 months, respectively). CONCLUSION: Transcatheter arterial embolisation effectively relieved pain in patients with mild-to-moderate osteoarthritis. In patients with severe osteoarthritis, pain severity decreased for 1 month but gradually increased to the initial severity score within 3 months. LEVEL OF EVIDENCE: 4, Case series.
PURPOSE: This retrospective study was conducted to compare the clinical outcomes of transcatheter arterial embolisation for chronic knee pain in patients with mild-to-moderate versus severe knee osteoarthritis. MATERIALS AND METHODS: This study included patients (n = 41) who were refractory to conservative treatments and who underwent transcatheter arterial embolisation using imipenem/cilastatin sodium between June 2017 and July 2018. A total of 71 knees, including 30 bilateral cases, were treated and categorised into two groups according to the Kellgren-Lawrence grade: mild-to-moderate osteoarthritis (n = 59, Kellgren-Lawrence grade 1-3) and severe osteoarthritis (n = 12, Kellgren-Lawrence grade 4). The clinical outcomes were measured by the visual analogue scale score. RESULTS: There were no significant differences in age, body mass index or baseline visual analogue scale scores between the two groups. The mean visual analogue scale scores in the mild-to-moderate osteoarthritis group were significantly decreased at 1 day, 1 week, 1 month, 3 months, and 6-months (5.5 at baseline vs. 3.2, 3.1, 2.9, 2.2, and 1.9, after treatment; all P = .00). These improvements were maintained at a mean of 10 ± 3 months (range 6-19 months) post-treatment. The visual analogue scale scores were significantly decreased in the severe osteoarthritis group for 1 month post-treatment (6.3 at baseline vs. 4.1, 4.1, and 4.4 at 1 day, 1 week, and 1 month; all P < .01). However, a decrease in pain was not statistically significant from 3 to 6 months (5.4 and 5.9 at 3 months and 6 months, respectively). CONCLUSION: Transcatheter arterial embolisation effectively relieved pain in patients with mild-to-moderate osteoarthritis. In patients with severe osteoarthritis, pain severity decreased for 1 month but gradually increased to the initial severity score within 3 months. LEVEL OF EVIDENCE: 4, Case series.
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