Ganes C Sen1, Bryan R G Williams2,3. 1. Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA. seng@ccf.org. 2. Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA. 3. Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia.