Literature DB >> 31332478

Intra-arterial chemotherapy for retinoblastoma: the dosimetric impact.

Andrea Guasti1, Sara Leonini2, Eugenio Bertelli3, Roberta Baldi4, Paola Gennari5, Samuele Cioni5, Ignazio Maria Vallone5, Daniele Giuseppe Romano5, Tommaso Casseri6, Leonardo Guerrini7, Annunziata Elena La Rocca7, Paolo Gambini Della Scala5, Sonia De Francesco8, Theodora Hadjistilianou8, Sandra Bracco5.   

Abstract

PURPOSE: Purposes are (1) to measure main radiation parameters and (2) to propose a method to estimate the absorbed doses of internal organs starting from DAP values. Measuring the exposition of internal organs by repeated irradiations on an anthropomorphic phantom with the same settings used in vivo, we could establish correlations between (1) DAP and the dose recorded by a dosimeter placed along the X-ray beam entrance pathway; (2) the dose recorded by the same dosimeter and the absorbed dose in internal organs.
METHODS: Forty-four consecutive patients (16 males, 28 females) (mean age 35.4 months) treated at our institution with IAC (216 procedures: 196 via the ICA and 20 into branches of the ECA) were included in this prospective study. IAC was divided into 5 phases. Fluoroscopic time, DAP, and ESD were measured.
RESULTS: The mean DAP was 595 ± 445 cGy cm2 and the mean fluoroscopic time was 540 ± 403 s. ESD was on average 9.59 mGy (range 0.8-165 mGy). The absorbed dose was lower than 12.1 mGy in the left retina (the more exposed organ) in 75% of single treatments and lower than 25 mGy in 95% of treatments. In the cases of 3 and 6 sessions, the left retina of 75% of patients absorbed respectively less than 36.3 and 72.7 mGy, whereas the left retina of 95% of patients received less than 75.2 and 150.4 mGy. Other organs were less exposed.
CONCLUSION: This paper describes a method of absorbed dose estimation providing ranges used clinically in a single practice and the basis for further prospective studies.

Entities:  

Keywords:  Absorbed dose; Dose exposition; Intra-arterial chemotherapy; Radiation parameters; Retinoblastoma

Year:  2019        PMID: 31332478     DOI: 10.1007/s00234-019-02260-7

Source DB:  PubMed          Journal:  Neuroradiology        ISSN: 0028-3940            Impact factor:   2.804


  5 in total

1.  Thoughts on "Estimation of radiation exposure of children undergoing superselective intra-arterial chemotherapy for retinoblastoma treatment: assessment of local diagnostic reference levels as a function of age, sex, and interventional success".

Authors:  Sara Leonini; Eugenio Bertelli; Sandra Bracco; Andrea Guasti
Journal:  Neuroradiology       Date:  2020-10-19       Impact factor: 2.804

Review 2.  The Role of Intraarterial Chemotherapy in the Management of Retinoblastoma.

Authors:  Aleksandra Pekacka
Journal:  J Ophthalmol       Date:  2020-01-24       Impact factor: 1.909

3.  Retinoblastoma Is Characterized by a Cold, CD8+ Cell Poor, PD-L1- Microenvironment, Which Turns Into Hot, CD8+ Cell Rich, PD-L1+ After Chemotherapy.

Authors:  Clelia Miracco; Paolo Toti; Maria Chiara Gelmi; Sara Aversa; Gennaro Baldino; Paolo Galluzzi; Sonia De Francesco; Federica Petrelli; Ester Sorrentino; Giuseppe Belmonte; Daniela Galimberti; Sandra Bracco; Theodora Hadjistilianou
Journal:  Invest Ophthalmol Vis Sci       Date:  2021-02-01       Impact factor: 4.799

4.  Thoughts on "Estimation of radiation exposure of children undergoing superselective, intra-arterial chemotherapy for retinoblastoma treatment: Assessment of Local Diagnostic Reference Levels as a function of age, sex and interventional success".

Authors:  Marcel Opitz; Axel Wetter; Nika Guberina
Journal:  Neuroradiology       Date:  2020-11-03       Impact factor: 2.804

5.  Comparison of Intra-Arterial Chemotherapy Efficacy Delivered Through the Ophthalmic Artery or External Carotid Artery in a Cohort of Retinoblastoma Patients.

Authors:  Shichong Jia; Xuyang Wen; Min Zhou; Xiaoyu He; Minglei Han; Jiayan Fan; Renbing Jia; Xianqun Fan
Journal:  Front Med (Lausanne)       Date:  2021-06-11
  5 in total

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