Literature DB >> 31332447

Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children With Nontuberculous Mycobacterial Infection.

Tiffany A Claeys1, Oscar Rosas Mejia1, Samuel Marshall2, Jason A Jarzembowski3, Don Hayes4, Natalie M Hull5, Namal P M Liyanage1, Robert H Chun6, Cecille G Sulman6, Anna R Huppler2,7, Richard T Robinson1.   

Abstract

Nontuberculous mycobacteria (NTM) infect children with increasing frequency worldwide. Using blood and lymph node tissue from children with NTM lymphadenitis, and uninfected lymph node tissue from community controls, we evaluated helper T (TH) cells in functional assays of TH1/TH17 differentiation and measured the concentration of their associated cytokines at the site of infection. Circulating TH cells from infected children were attenuated in their TH1/TH17 differentiation capacity and expressed less interferon γ and interleukin 17 after polyclonal stimulation. Similar differences were observed at the site of infection, where most cytokine concentrations were unchanged relative to controls. Our data are consistent with a model wherein TH1/TH17 differentiation is attenuated in NTM-infected children.
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  NTM; Nontuberculous; TH1 and TH17 cells; children; immune; mycobacteria; pediatric

Mesh：

Substances：

Year:  2019        PMID： 31332447      PMCID： PMC7325325          DOI： 10.1093/infdis/jiz371

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

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3.  In the presence of IL-21 human cord blood T cells differentiate to IL-10-producing Th1 but not Th17 or Th2 cells.

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4.  Pulmonary nontuberculous mycobacterial disease: prospective study of a distinct preexisting syndrome.

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Journal:  Am J Respir Crit Care Med       Date:  2008-08-14       Impact factor: 21.405

5.  Increase in Childhood Nontuberculous Mycobacterial Infections After Bacille Calmette-Guérin Coverage Drop: A Nationwide, Population-Based Retrospective Study, Finland, 1995-2016.

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6.  The many lives of nontuberculous mycobacteria.

Authors:  Tiffany A Claeys; Richard T Robinson
Journal:  J Bacteriol       Date:  2018-02-26       Impact factor: 3.490

7.  Host response to nontuberculous mycobacterial infections of current clinical importance.

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8.  Mycobacterial lymphadenitis in children: a prospective study of 105 nontuberculous cases with long-term follow-up.

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Review 9.  Non-tuberculous mycobacteria in children: muddying the waters of tuberculosis diagnosis.

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10.  US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis: executive summary.

Authors:  R Andres Floto; Kenneth N Olivier; Lisa Saiman; Charles L Daley; Jean-Louis Herrmann; Jerry A Nick; Peadar G Noone; Diana Bilton; Paul Corris; Ronald L Gibson; Sarah E Hempstead; Karsten Koetz; Kathryn A Sabadosa; Isabelle Sermet-Gaudelus; Alan R Smyth; Jakko van Ingen; Richard J Wallace; Kevin L Winthrop; Bruce C Marshall; Charles S Haworth
Journal:  Thorax       Date:  2016-01       Impact factor: 9.139
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2.  Exacerbation of Mycobacterium avium pulmonary infection by comorbid allergic asthma is associated with diminished mycobacterium-specific Th17 responses.

Authors:  Yeeun Bak; Sang Chul Park; Dahee Shim; Yura Ha; Jumi Lee; Hongmin Kim; Kee Woong Kwon; Joo-Heon Yoon; Sung Jae Shin
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  2 in total

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