| Literature DB >> 31332195 |
Augusto Anguita-Ruiz1,2,3,4, Julio Plaza-Diaz5,6,7, Francisco Javier Ruiz-Ojeda5,7,8, Azahara I Rupérez5,9,10, Rosaura Leis11,12, Gloria Bueno11,9,10, Mercedes Gil-Campos11,13, Rocío Vázquez-Cobela11,12, Ramón Cañete11,13, Luis A Moreno9, Ángel Gil5,6,7,11, Concepción María Aguilera5,6,7,11.
Abstract
X chromosome genetic variation has been proposed as a potential source of missing heritability for many complex diseases, including obesity. Currently, there is a lack of public available genetic datasets incorporating X chromosome genotype data. Although several X chromosome-specific statistics have been developed, there is also a lack of readily available implementations for routine analysis. Here, we aimed: (1) to make public and describe a dataset incorporating phenotype and X chromosome genotype data from a cohort of 915 normal-weight, overweight and obese children, and (2) to deeply describe a whole implementation of the special X chromosome analytic process in genetics. Datasets and pipelines like this are crucial to get familiar with the steps in which X chromosome requires special attention and may raise awareness of the importance of this genomic region.Entities:
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Year: 2019 PMID： 31332195 PMCID： PMC6646348 DOI： 10.1038/s41597-019-0109-3
Source DB: PubMed Journal: Sci Data ISSN： 2052-4463 Impact factor: 6.444