Marilisa Gabardo1, João Zielak2, Gabriela Tórtora1, Jennifer Gerber1, Michelle Meger1, Nelson Rebellato3, Erika Küchler1, Rafaela Scariot1. 1. School of Health Sciences, Universidade Positivo, Rua Prof. Pedro Viriato Parigot de Souza 5300, Curitiba, Paraná, 81280-330, Brazil. 2. School of Health Sciences, Universidade Positivo, Rua Prof. Pedro Viriato Parigot de Souza 5300, Curitiba, Paraná, 81280-330, Brazil. Electronic address: jzielak2@gmail.com. 3. Department of Stomatology, School of Dentistry of Universidade Federal do Paraná, Avenida Prefeito Lothário Meissner 632, Curitiba, Paraná 80210-170, Brazil.
Abstract
INTRODUCTION: Dentofacial deformities have an impact on quality of life (QOL). Many factors can influence this perception, including genetic aspects. ANKK1 and DRD2 genes are associated with dopaminergic system and could modulate behavioral dysfunction. PURPOSE: The impact of orthognathic surgery and associated factors on QOL of adults was evaluated. MATERIAL AND METHODS: The abbreviated World Health Organization Quality of Life questionnaire (WHOQOL-BREF) was applied to patients from two surgery services one week before (T0) and six months after surgery (T1). The independent variables were age, sex, race, facial pattern, presence of jaw asymmetry and vertical deformities, and polymorphisms associated with ANKK1 and DRD2 genes. Descriptive and bivariate analyses were performed. RESULTS: There was improvement in the perception of QOL from T0 to T1 in the general score, in the physical and psychological domains, and in the quality of life and general health perception (QOLGHP) (p < 0.001). In this interval, individuals aged ≥30 years reported positive impacts on all outcomes (p < 0.05), whereas in women this improvement did not occur only for the physical domain (p = 0.136). There was an association between the polymorphisms associated with the ANKK1 gene (rs1800497) and the perception of QOL in the social relationship's domain (p = 0.021) and QOLGHP (p = 0.042). The other clinical conditions were not associated with outcomes (p > 0.05). CONCLUSION: Perception of QOL of patients improved following orthognathic surgery in physical, psychological, and QOLGHP domains. Aged ≥30 years, being women and polymorphisms associated with the ANKK1 gene were related to positive impacts.
INTRODUCTION:Dentofacial deformities have an impact on quality of life (QOL). Many factors can influence this perception, including genetic aspects. ANKK1 and DRD2 genes are associated with dopaminergic system and could modulate behavioral dysfunction. PURPOSE: The impact of orthognathic surgery and associated factors on QOL of adults was evaluated. MATERIAL AND METHODS: The abbreviated World Health Organization Quality of Life questionnaire (WHOQOL-BREF) was applied to patients from two surgery services one week before (T0) and six months after surgery (T1). The independent variables were age, sex, race, facial pattern, presence of jaw asymmetry and vertical deformities, and polymorphisms associated with ANKK1 and DRD2 genes. Descriptive and bivariate analyses were performed. RESULTS: There was improvement in the perception of QOL from T0 to T1 in the general score, in the physical and psychological domains, and in the quality of life and general health perception (QOLGHP) (p < 0.001). In this interval, individuals aged ≥30 years reported positive impacts on all outcomes (p < 0.05), whereas in women this improvement did not occur only for the physical domain (p = 0.136). There was an association between the polymorphisms associated with the ANKK1 gene (rs1800497) and the perception of QOL in the social relationship's domain (p = 0.021) and QOLGHP (p = 0.042). The other clinical conditions were not associated with outcomes (p > 0.05). CONCLUSION: Perception of QOL of patients improved following orthognathic surgery in physical, psychological, and QOLGHP domains. Aged ≥30 years, being women and polymorphisms associated with the ANKK1 gene were related to positive impacts.
Authors: Bernardo Olsson; Mateus José da Silva; Camila Lago; Robson Diego Calixto; Lucas Alexandre Ramazzotto; Nelson Luis Barbosa Rebellato; Christian Kirschneck; Francisco Wanderley Garcia Paula-Silva; Erika Calvano Küchler; Rafaela Scariot Journal: Ann Maxillofac Surg Date: 2022-02-01