Margot Baudelet1,2,3, Leen Van den Steen3,4, Peter Tomassen5, Katrien Bonte5, Philippe Deron5,6, Wouter Huvenne5,6, Sylvie Rottey7,8, Wilfried De Neve1,2, Nora Sundahl1, Gwen Van Nuffelen3,4,9, Fréderic Duprez1,2. 1. Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium. 2. Faculty of Medicine and Health Sciences, Department of Human Structure and Repair, Ghent University, Ghent, Belgium. 3. Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. 4. Department of Otolaryngology and Head & Neck Surgery-Rehabilitation Center for Communication Disorders, Antwerp University Hospital, Antwerp, Belgium. 5. Department of Head and Neck Surgery, Ghent University Hospital, Ghent, Belgium. 6. Faculty of Medicine and Health Sciences, Department of Head and Skin, Ghent University, Ghent, Belgium. 7. Department of Medical Oncology, Ghent University Hospital, Ghent, Belgium. 8. Faculty of Medicine and Health Sciences, Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium. 9. Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
Abstract
BACKGROUND: Acute and late toxicity after intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC) impacts on patient quality of life; yet, very late toxicity data remain scarce. This study assessed dysphagia, xerostomia, and neck fibrosis 3-8 years after IMRT. METHODS: A retrospective analysis using generalized estimated equations was performed on 60 patients with HNC treated with fractionated IMRT between 2000 and 2015 who had a follow-up ≥8 years. Toxicity was scored using LENT-SOMA scales. RESULTS: A trend towards a nonlinear global time effect (P = .05) was noted for dysphagia with a decrease during the 5 years post-treatment and an increase thereafter. A significant decrease in xerostomia (P = .001) and an increase in neck fibrosis (P = .04) was observed until 8 years. CONCLUSIONS: Dysphagia, xerostomia, and neck fibrosis do not appear stable over time and remain highly prevalent in the very late follow-up. Our findings support the need for prospective trials investigating very late toxicity in patients with HNC.
BACKGROUND: Acute and late toxicity after intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC) impacts on patient quality of life; yet, very late toxicity data remain scarce. This study assessed dysphagia, xerostomia, and neck fibrosis 3-8 years after IMRT. METHODS: A retrospective analysis using generalized estimated equations was performed on 60 patients with HNC treated with fractionated IMRT between 2000 and 2015 who had a follow-up ≥8 years. Toxicity was scored using LENT-SOMA scales. RESULTS: A trend towards a nonlinear global time effect (P = .05) was noted for dysphagia with a decrease during the 5 years post-treatment and an increase thereafter. A significant decrease in xerostomia (P = .001) and an increase in neck fibrosis (P = .04) was observed until 8 years. CONCLUSIONS:Dysphagia, xerostomia, and neck fibrosis do not appear stable over time and remain highly prevalent in the very late follow-up. Our findings support the need for prospective trials investigating very late toxicity in patients with HNC.
Authors: Hanne Massonet; Ann Goeleven; Leen Van den Steen; Alice Vergauwen; Margot Baudelet; Gilles Van Haesendonck; Olivier Vanderveken; Heleen Bollen; Lisette van der Molen; Fréderic Duprez; Peter Tomassen; Sandra Nuyts; Gwen Van Nuffelen Journal: Trials Date: 2022-10-22 Impact factor: 2.728
Authors: Paul Ramia; Larry Bodgi; Dima Mahmoud; Mohammad A Mohammad; Bassem Youssef; Neil Kopek; Humaid Al-Shamsi; Mona Dagher; Ibrahim Abu-Gheida Journal: Clin Med Insights Oncol Date: 2022-01-30