Literature DB >> 3132916

Heparin inhibits the inositol 1,4,5-trisphosphate-dependent, but not the independent, calcium release induced by guanine nucleotide in vascular smooth muscle.

S Kobayashi1, A V Somlyo, A P Somlyo.   

Abstract

The effects of heparin on the release of intracellular Ca2+, assessed by tension development in saponin-permeabilized rabbit main pulmonary artery, were determined. Heparin inhibited (IC50 = 5 micrograms/ml) inositol 1,4,5-trisphosphate (InsP3)-induced, but not caffeine-induced, Ca2+ release. The initial (InsP3-dependent) component of GTP gamma S-induced Ca2+-release was also inhibited by heparin, but the InsP3-independent component was resistant to both heparin and procaine. These results support the existence of a G protein activated mechanism of Ca2+ release that is not mediated by InsP3 or by Ca2+-induced Ca2+ release.

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Year:  1988        PMID： 3132916     DOI： 10.1016/s0006-291x(88)81141-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  35 in total

1.  Role of calcium stores and membrane voltage in the generation of slow wave action potentials in guinea-pig gastric pylorus.

Authors:  D F van Helden; M S Imtiaz; K Nurgaliyeva; P von der Weid; P J Dosen
Journal:  J Physiol       Date:  2000-04-01       Impact factor: 5.182

2.  ATP-induced endothelium-independent enhancement of lymphatic vasomotion in guinea-pig mesentery involves P2X and P2Y receptors.

Authors:  Jun Zhao; Dirk F van Helden
Journal:  Br J Pharmacol       Date:  2002-10       Impact factor: 8.739

3.  ATP activates cationic currents and modulates the calcium current through GTP-binding protein in rabbit portal vein.

Authors:  Z L Xiong; K Kitamura; H Kuriyama
Journal:  J Physiol       Date:  1991       Impact factor: 5.182

4.  Growth of Pollen Tubes of Papaver rhoeas Is Regulated by a Slow-Moving Calcium Wave Propagated by Inositol 1,4,5-Trisphosphate.

Authors:  V. E. Franklin-Tong; B. K. Drobak; A. C. Allan; PAC. Watkins; A. J. Trewavas
Journal:  Plant Cell       Date:  1996-08       Impact factor: 11.277

5.  Activation of the calcium release channel (ryanodine receptor) by heparin and other polyanions is calcium dependent.

Authors:  I B Bezprozvanny; K Ondrias; E Kaftan; D A Stoyanovsky; B E Ehrlich
Journal:  Mol Biol Cell       Date:  1993-03       Impact factor: 4.138

Review 6.  Regulation of smooth muscle cell growth by endothelium-derived factors.

Authors:  T Scott-Burden; P M Vanhoutte
Journal:  Tex Heart Inst J       Date:  1994

7.  Efficacy of peak Ca2+ currents (ICa) as trigger of sarcoplasmic reticulum Ca2+ release in myocytes from the guinea-pig coronary artery.

Authors:  G Isenberg
Journal:  J Physiol       Date:  1995-04-15       Impact factor: 5.182

8.  Ca2+ influx through carbachol-activated non-selective cation channels in guinea-pig gastric myocytes.

Authors:  S J Kim; E M Koh; T M Kang; Y C Kim; I So; G Isenberg; K W Kim
Journal:  J Physiol       Date:  1998-12-15       Impact factor: 5.182

9.  Calcium release induced by inositol 1,4,5-trisphosphate in single rabbit intestinal smooth muscle cells.

Authors:  S Komori; T B Bolton
Journal:  J Physiol       Date:  1991-02       Impact factor: 5.182

10.  Subcellular distribution of the calcium-storing inositol 1,4,5-trisphosphate-sensitive organelle in rat liver. Possible linkage to the plasma membrane through the actin microfilaments.

Authors:  M F Rossier; G S Bird; J W Putney
Journal:  Biochem J       Date:  1991-03-15       Impact factor: 3.857
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