Literature DB >> 3132899

Sodium aurothiomalate does not block interleukin 1 production in rabbits.

Y Zurovsky1, H P Laburn, D Mitchell, A Ruck.   

Abstract

Gold salts may attenuate inflammatory processes by inhibiting interleukin 1 production. It is shown that sodium aurothiomalate does not act as an antipyretic after intravenous injection of two pyrogens into rabbits. Consequently, it cannot suppress interleukin 1 production, a conclusion confirmed by an in vitro lymphocyte activating factor assay. Chronic sodium aurothiomalate treatment, however, did depress the blood leucocyte count significantly.

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Year:  1988        PMID： 3132899      PMCID： PMC1003555          DOI： 10.1136/ard.47.6.506

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  3 in total

1.  Selective concentration and localization of gold in macrophages of synovial and other tissues during and after chrysotherapy in rheumatoid patients.

Authors:  B Vernon-Roberts; J L Doré; J D Jessop; W J Henderson
Journal:  Ann Rheum Dis       Date:  1976-12       Impact factor: 19.103

Review 2.  The macrophage as a secretory cell in chronic inflammation.

Authors:  P Davies; A C Allison
Journal:  Agents Actions       Date:  1976-02

3.  Effect of aurothiomalate on human mononuclear blood cells cultured in vitro.

Authors:  K E Viken; J O Lamvik
Journal:  Acta Pathol Microbiol Scand C       Date:  1976-10
  3 in total
  1 in total

1.  The effect of gold sodium thiomalate and auranofin on lipopolysaccharide-induced interleukin-1 production by blood monocytes in vitro: variation in healthy subjects and patients with arthritis.

Authors:  V A Danis; A J Kulesz; D S Nelson; P M Brooks
Journal:  Clin Exp Immunol       Date:  1990-03       Impact factor: 4.330
  1 in total

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