Literature DB >> 3132881

Role of the 15-lipoxygenase in the immune system.

J Y Vanderhoek1.   

Abstract

Recent data from our laboratory, as well as supporting evidence from other investigators, strongly suggest that the PMN 15-LO exists in a cryptic state. Several stimuli, including HETEs, can convert the inactive 15-LO to an active species that can metabolize AA to a variety of products. Many of these metabolites have been reported to modulate various components of the immune response.

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Year:  1988        PMID： 3132881     DOI： 10.1111/j.1749-6632.1988.tb38547.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  2 in total

1.  Structural characterization of monohydroxyeicosatetraenoic acids and dihydroxy- and trihydroxyeicosatrienoic acids by ESI-FTICR.

Authors:  Lijie Cui; Marilyn A Isbell; Yuttana Chawengsub; John R Falck; William B Campbell; Kasem Nithipatikom
Journal:  J Am Soc Mass Spectrom       Date:  2008-01-31       Impact factor: 3.109

2.  The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.

Authors:  Luisa Klotz; Sven Burgdorf; Indra Dani; Kaoru Saijo; Juliane Flossdorf; Stephanie Hucke; Judith Alferink; Nina Nowak; Natalija Novak; Marc Beyer; Gunter Mayer; Birgit Langhans; Thomas Klockgether; Ari Waisman; Gerard Eberl; Joachim Schultze; Michael Famulok; Waldemar Kolanus; Christopher Glass; Christian Kurts; Percy A Knolle
Journal:  J Exp Med       Date:  2009-09-08       Impact factor: 14.307
  2 in total

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