Literature DB >> 31328584

Interleukin-6 Receptor (IL-6R) Expression in Human Gastric Carcinoma and its Clinical Significance.

C Simondurairaj1, R Krishnakumar1, Sandhya Sundaram1, Ganesh Venkatraman2.   

Abstract

The aim of the study is to analyse the expression of Interleukin-6 receptor in different human gastric tissue and to correlate with the clinicopathological features of the patients. Immunohistochemistry was done against the IL-6R antibody and the Q-score was calculated from the staining pattern. Higher Q-scores were observed in tumour cells than the adjacent normal cells which were statistically significant. We also observed a significant correlation between the expressions of IL-6R and the clinicopathological features These findings suggest that IL-6R may represent as a therapeutic target for gastric carcinoma and serve as a prognostic indicator, as well.

Entities:  

Keywords:  Cytokine; Interleukin-6 receptor; gastric cancer; immunohistochemistry; prognostic marker

Mesh：

Substances：

Year:  2019        PMID： 31328584     DOI： 10.1080/07357907.2019.1638395

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  6 in total

1.  Expression of Interleukin-6 and the Interleukin-6 Receptor Predicts the Clinical Outcomes of Patients with Soft Tissue Sarcomas.

Authors:  Koichi Nakamura; Tomoki Nakamura; Takahiro Iino; Tomohito Hagi; Kouji Kita; Kunihiro Asanuma; Akihiro Sudo
Journal:  Cancers (Basel)       Date:  2020-03-03       Impact factor: 6.639

Review 2.  Impact of Gastrointestinal Symptoms in COVID-19: a Molecular Approach.

Authors:  Dharmendra Kashyap; Nidhi Varshney; Charu Sonkar; Budhadev Baral; Hem Chandra Jha
Journal:  SN Compr Clin Med       Date:  2020-11-04

3.  Apatinib inhibits gastric carcinoma development by regulating the expression levels of IL-17 via the Bax/Bcl-2 signaling pathway.

Authors:  Tianxi Wang; Jun Zhang; Lihong Cui
Journal:  Exp Ther Med       Date:  2021-04-19       Impact factor: 2.447

4.  Increased expression of interleukin-6 gene in gastritis and gastric cancer.

Authors:  M P Santos; J N Pereira; R W Delabio; M A C Smith; S L M Payão; L C Carneiro; M S Barbosa; L T Rasmussen
Journal:  Braz J Med Biol Res       Date:  2021-05-17       Impact factor: 2.590

5.  Effects of Helicobacter pylori infection and interleukin 6 on the expression of ITIH4 in human gastric cancer cells.

Authors:  Dadao Jing; Jie Jin; Zhu Mei; Qingqing Zhu; Yingying Lu; Xingpeng Wang
Journal:  Transl Cancer Res       Date:  2020-08       Impact factor: 1.241

Review 6.  Peripheral Cytokine Levels as a Prognostic Indicator in Gastric Cancer: A Review of Existing Literature.

Authors:  Elton Yang; Wei Chua; Weng Ng; Tara Laurine Roberts
Journal:  Biomedicines       Date:  2021-12-14
  6 in total

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