| Literature DB >> 31328197 |
Yefeng Chen1, Minqiu Xu1, Weipan Xu1, Heng Song1, Liqiang Hu1, Shuyuan Xue1, Shuangzhan Zhang1, Xiana Qian1, Hexin Xie1.
Abstract
Reported herein is a relebactam-derived fluorogenic reagent for covalent labeling of serine β-lactamases (SBLs), which are the major causes of bacterial resistance to β-lactam antibiotics. This highly selective imaging reagent generates over 300-fold stronger near-infrared fluorescence signals upon covalently bonding to SBLs, allowing wash-free visualization of live antimicrobial-resistant bacteria.Entities:
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Year: 2019 PMID： 31328197 DOI： 10.1039/c9cc04533c
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222