Literature DB >> 31327676

Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues.

Zhiming Cheng1, Wagner O Valença2, Gleiston G Dias2, Jamie Scott1, Nicole D Barth1, Fabio de Moliner1, Gabriela B P Souza2, Richard J Mellanby3, Marc Vendrell4, Eufrânio N da Silva Júnior5.   

Abstract

Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2019        PMID： 31327676     DOI： 10.1016/j.bmc.2019.07.017

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  2 in total

1.  It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity.

Authors:  Daisy J B Lima; Renata G Almeida; Guilherme A M Jardim; Breno P A Barbosa; Augusto C C Santos; Wagner O Valença; Marcos R Scheide; Claudia C Gatto; Guilherme G C de Carvalho; Pedro M S Costa; Claudia Pessoa; Cynthia L M Pereira; Claus Jacob; Antonio L Braga; Eufrânio N da Silva Júnior
Journal:  RSC Med Chem       Date:  2021-08-12

2.  Correction: A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells.

Authors:  Ya Zhu; Jialing Han; Qian Zhang; Zhou Zhao; Jin Wang; Xiaowei Xu; Haiping Hao; Jun Zhang
Journal:  RSC Adv       Date:  2019-10-25       Impact factor: 3.361
  2 in total

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