Julie Aarestrup1, Cari M Kitahara2, Jennifer L Baker3. 1. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Nordre Fasanvej 57, 2000, Frederiksberg, Denmark. 2. Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA. 3. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Nordre Fasanvej 57, 2000, Frederiksberg, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark. Electronic address: Jennifer.Lyn.Baker@regionh.dk.
Abstract
BACKGROUND: The aetiology of thyroid cancer is poorly understood, but it is possible that this malignancy has origins early in life. It is, however, currently unknown if birthweight, as an indicator of prenatal growth, is related to thyroid cancer risk. OBJECTIVE: To investigate if birthweight is associated with the later risk of thyroid cancer and its histological types. METHODS: 246,141 children (120,505 girls, 125,636 boys) from the Copenhagen School Health Records Register, born 1936-1989, were prospectively followed in the Danish Cancer Registry. Cox regressions were used to estimate hazards ratios (HR) and 95% confidence intervals (CI). RESULTS: During follow up, 241 individuals (172 women, 69 men) were diagnosed with thyroid cancer (162 papillary, 53 follicular). Birthweight was significantly and positively associated with risk of thyroid cancer overall (HR = 1.30 [95% CI: 1.03-1.64] per kilogram). There were no sex differences in the associations. Birthweight was positively and significantly associated with follicular thyroid cancer (HR = 1.74 [95% CI: 1.07-2.82] per kilogram), and although there was an indication of a positive association, it did not reach statistical significance for the more common papillary type (HR = 1.20 [95% CI: 0.90-1.59] per kilogram). CONCLUSION: A heavier weight at birth is associated with an elevated risk of total and follicular thyroid cancer, which underscores that prenatal exposures may be important in thyroid cancer aetiology.
BACKGROUND: The aetiology of thyroid cancer is poorly understood, but it is possible that this malignancy has origins early in life. It is, however, currently unknown if birthweight, as an indicator of prenatal growth, is related to thyroid cancer risk. OBJECTIVE: To investigate if birthweight is associated with the later risk of thyroid cancer and its histological types. METHODS: 246,141 children (120,505 girls, 125,636 boys) from the Copenhagen School Health Records Register, born 1936-1989, were prospectively followed in the Danish Cancer Registry. Cox regressions were used to estimate hazards ratios (HR) and 95% confidence intervals (CI). RESULTS: During follow up, 241 individuals (172 women, 69 men) were diagnosed with thyroid cancer (162 papillary, 53 follicular). Birthweight was significantly and positively associated with risk of thyroid cancer overall (HR = 1.30 [95% CI: 1.03-1.64] per kilogram). There were no sex differences in the associations. Birthweight was positively and significantly associated with follicular thyroid cancer (HR = 1.74 [95% CI: 1.07-2.82] per kilogram), and although there was an indication of a positive association, it did not reach statistical significance for the more common papillary type (HR = 1.20 [95% CI: 0.90-1.59] per kilogram). CONCLUSION: A heavier weight at birth is associated with an elevated risk of total and follicular thyroid cancer, which underscores that prenatal exposures may be important in thyroid cancer aetiology.
Authors: Julie Aarestrup; Lise G Bjerregaard; Kathrine D Meyle; Dorthe C Pedersen; Line K Gjærde; Britt W Jensen; Jennifer L Baker Journal: Int J Obes (Lond) Date: 2020-01-23 Impact factor: 5.095
Authors: Cari M Kitahara; Dagrun Slettebø Daltveit; Anders Ekbom; Anders Engeland; Mika Gissler; Ingrid Glimelius; Tom Grotmol; Ylva Trolle Lagerros; Laura Madanat-Harjuoja; Tuija Männistö; Henrik Toft Sørensen; Rebecca Troisi; Tone Bjørge Journal: Lancet Diabetes Endocrinol Date: 2020-12-18 Impact factor: 32.069
Authors: David J Cote; Timothy R Smith; Ursula B Kaiser; Edward R Laws; Meir J Stampfer Journal: J Clin Endocrinol Metab Date: 2021-03-25 Impact factor: 5.958