Lan T Ho-Pham1, Bich Tran2, An T Do3, Tuan V Nguyen4. 1. Bone and Muscle Research Group, Ton Duc Thang University, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Viet Nam. Electronic address: hophamthuclan@tdtu.edu.vn. 2. Bone and Muscle Research Group, Ton Duc Thang University, Viet Nam; Centre for Big Data Research in Health, UNSW Sydney, Australia. 3. Bone and Muscle Research Group, Ton Duc Thang University, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Viet Nam. 4. Bone and Muscle Research Group, Ton Duc Thang University, Viet Nam; School of Biomedical Engineering, University of Technology Sydney, Australia; Bone Biology Division, Garvan Institute of Medical Research, Sydney, Australia.
Abstract
AIMS: Trabecular bone score (TBS) is a surrogate indicator of bone microarchitecture. The present study sought to examine the association between type 2 diabetes (T2D) and trabecular bone score (TBS) in adult Vietnamese men and women. METHODS: The study was part of the Vietnam Osteoporosis Study, in which 2702 women and 1398 men aged ≥30 years were recruited from the general community in Ho Chi Minh City. HbA1c levels were measured by the ADAMS™ A1c HA-8160 (Arkray, Kyoto, Japan), and classified into 3 groups: normal if HbA1c < 5.7%; pre-diabetes (5.7-6.4%); and diabetes (>6.4%). TBS was evaluated by iNsight Software, version 2.1 (Medimaps, Merignac, France) on lumbar spine BMD scan (Hologic Horizon). Differences in TBS between diabetic status were analyzed by the multivariable regression model with adjustment for age and body mass index. RESULTS: The prevalence of pre-diabetes and diabetes in men and women was 30.2% and 8.3%, respectively. In women, TBS was lower in pre-diabetes (-0.02; P < 0.001) and diabetes (-0.02; P < 0.001) compared with normal individuals. In men, there was no statistically significant difference in TBS between diabetic status. Moreover, TBS was significantly inversely correlated with HbA1c levels in women (P = 0.01), but not in men (P = 0.89). CONCLUSION: Women, but not men, with type 2 diabetes and pre-diabetes have lower TBS than individuals without diabetes. These data suggest that diabetes and prediabetes are associated with deterioration of bone microarchitecture.
AIMS: Trabecular bone score (TBS) is a surrogate indicator of bone microarchitecture. The present study sought to examine the association between type 2 diabetes (T2D) and trabecular bone score (TBS) in adult Vietnamese men and women. METHODS: The study was part of the Vietnam Osteoporosis Study, in which 2702 women and 1398 men aged ≥30 years were recruited from the general community in Ho Chi Minh City. HbA1c levels were measured by the ADAMS™ A1c HA-8160 (Arkray, Kyoto, Japan), and classified into 3 groups: normal if HbA1c < 5.7%; pre-diabetes (5.7-6.4%); and diabetes (>6.4%). TBS was evaluated by iNsight Software, version 2.1 (Medimaps, Merignac, France) on lumbar spine BMD scan (Hologic Horizon). Differences in TBS between diabetic status were analyzed by the multivariable regression model with adjustment for age and body mass index. RESULTS: The prevalence of pre-diabetes and diabetes in men and women was 30.2% and 8.3%, respectively. In women, TBS was lower in pre-diabetes (-0.02; P < 0.001) and diabetes (-0.02; P < 0.001) compared with normal individuals. In men, there was no statistically significant difference in TBS between diabetic status. Moreover, TBS was significantly inversely correlated with HbA1c levels in women (P = 0.01), but not in men (P = 0.89). CONCLUSION:Women, but not men, with type 2 diabetes and pre-diabetes have lower TBS than individuals without diabetes. These data suggest that diabetes and prediabetes are associated with deterioration of bone microarchitecture.
Authors: Albert Shieh; Gail A Greendale; Jane A Cauley; Carrie Karvonen-Gutierriez; Sioban D Harlow; Joel S Finkelstein; Diana Liao; Mei-Hua Huang; Arun S Karlamangla Journal: Osteoporos Int Date: 2022-02-17 Impact factor: 5.071
Authors: Linsey U Gani; Kundan R Saripalli; Karen Fernandes; Suet F Leong; Koh T Tsai; Pei T Tan; Le R Chong; Thomas F J King Journal: PLoS One Date: 2020-11-19 Impact factor: 3.240