Literature DB >> 31325527

Small changes, big implications: The impact of m6A RNA methylation on gene expression in pluripotency and development.

Adam M Heck1, Carol J Wilusz2.   

Abstract

In order to maintain a state of self-renewal, yet retain the ability to rapidly differentiate in response to external signals, pluripotent cells exert tight control over gene expression at many levels. Recent studies have suggested that N6-methyladenosine (m6A) RNA methylation, one of the most abundant post-transcriptional modifications, is important for both pluripotency and differentiation. In this review, we summarize the current state of the m6A field, with emphasis on the impact of writers, erasers and readers of m6A on RNA metabolism and stem cell biology.
Copyright © 2019 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Development; Pluripotency; RNA modification; Stem cells; m(6)A methylation

Mesh：

Substances：

Year:  2019        PMID： 31325527      PMCID： PMC6742438          DOI： 10.1016/j.bbagrm.2019.07.003

Source DB:  PubMed          Journal:  Biochim Biophys Acta Gene Regul Mech        ISSN： 1874-9399            Impact factor:   4.490


  190 in total

1.  Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.

Authors:  Chao Xu; Ke Liu; Hazem Ahmed; Peter Loppnau; Matthieu Schapira; Jinrong Min
Journal:  J Biol Chem       Date:  2015-08-28       Impact factor: 5.157

2.  5'-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA.

Authors:  C M Wei; A Gershowitz; B Moss
Journal:  Biochemistry       Date:  1976-01-27       Impact factor: 3.162

3.  The YTH domain is a novel RNA binding domain.

Authors:  Zhaiyi Zhang; Dominik Theler; Katarzyna H Kaminska; Michael Hiller; Pierre de la Grange; Rainer Pudimat; Ilona Rafalska; Bettina Heinrich; Janusz M Bujnicki; Frédéric H-T Allain; Stefan Stamm
Journal:  J Biol Chem       Date:  2010-02-18       Impact factor: 5.157

4.  Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis.

Authors:  Phillip J Hsu; Yunfei Zhu; Honghui Ma; Yueshuai Guo; Xiaodan Shi; Yuanyuan Liu; Meijie Qi; Zhike Lu; Hailing Shi; Jianying Wang; Yiwei Cheng; Guanzheng Luo; Qing Dai; Mingxi Liu; Xuejiang Guo; Jiahao Sha; Bin Shen; Chuan He
Journal:  Cell Res       Date:  2017-08-15       Impact factor: 25.617

Review 5.  The genetics of obesity: FTO leads the way.

Authors:  Katherine A Fawcett; Inês Barroso
Journal:  Trends Genet       Date:  2010-04-08       Impact factor: 11.639

6.  RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.

Authors:  Atsushi Tanabe; Kenya Tanikawa; Mai Tsunetomi; Kaori Takai; Hiroto Ikeda; Junpei Konno; Toshihiko Torigoe; Hideki Maeda; Goro Kutomi; Kenji Okita; Mitsuru Mori; Hiroeki Sahara
Journal:  Cancer Lett       Date:  2016-03-17       Impact factor: 8.679

7.  Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.

Authors:  Bastian Linder; Anya V Grozhik; Anthony O Olarerin-George; Cem Meydan; Christopher E Mason; Samie R Jaffrey
Journal:  Nat Methods       Date:  2015-06-29       Impact factor: 28.547

8.  The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline.

Authors:  Alexis S Bailey; Pedro J Batista; Rebecca S Gold; Y Grace Chen; Dirk G de Rooij; Howard Y Chang; Margaret T Fuller
Journal:  Elife       Date:  2017-10-31       Impact factor: 8.140

9.  Structural insights into the RNA methyltransferase domain of METTL16.

Authors:  Agnieszka Ruszkowska; Milosz Ruszkowski; Zbigniew Dauter; Jessica A Brown
Journal:  Sci Rep       Date:  2018-03-28       Impact factor: 4.379

10.  Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.

Authors:  Philip Knuckles; Tina Lence; Irmgard U Haussmann; Dominik Jacob; Nastasja Kreim; Sarah H Carl; Irene Masiello; Tina Hares; Rodrigo Villaseñor; Daniel Hess; Miguel A Andrade-Navarro; Marco Biggiogera; Mark Helm; Matthias Soller; Marc Bühler; Jean-Yves Roignant
Journal:  Genes Dev       Date:  2018-03-13       Impact factor: 11.361
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  13 in total

1.  Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination.

Authors:  Lekha Nair; Wanwei Zhang; Brice Laffleur; Mukesh K Jha; Junghyun Lim; Heather Lee; Lijing Wu; Nehemiah S Alvarez; Zhi-Ping Liu; Emilia L Munteanu; Theresa Swayne; Jacob H Hanna; Lei Ding; Gerson Rothschild; Uttiya Basu
Journal:  Mol Cell       Date:  2021-08-26       Impact factor: 19.328

2.  m6A RNA Methylation Regulators Contribute to Eutopic Endometrium and Myometrium Dysfunction in Adenomyosis.

Authors:  Junyu Zhai; Shang Li; Sushmita Sen; Jessica Opoku-Anane; Yanzhi Du; Zi-Jiang Chen; Linda C Giudice
Journal:  Front Genet       Date:  2020-07-03       Impact factor: 4.599

3.  YTHDF2 destabilizes m6A-modified neural-specific RNAs to restrain differentiation in induced pluripotent stem cells.

Authors:  Adam M Heck; Joseph Russo; Jeffrey Wilusz; Erin Osborne Nishimura; Carol J Wilusz
Journal:  RNA       Date:  2020-03-13       Impact factor: 4.942

Review 4.  The Roles of Base Modifications in Kidney Cancer.

Authors:  Chunyue Feng; Xiaoli Huang; Xuekun Li; Jianhua Mao
Journal:  Front Oncol       Date:  2020-11-13       Impact factor: 6.244

Review 5.  Novel Insights into Adipogenesis from the Perspective of Transcriptional and RNA N6-Methyladenosine-Mediated Post-Transcriptional Regulation.

Authors:  Tongxing Song; Yang Yang; Siwen Jiang; Jian Peng
Journal:  Adv Sci (Weinh)       Date:  2020-09-03       Impact factor: 16.806

6.  Context-dependent functional compensation between Ythdf m6A reader proteins.

Authors:  Lior Lasman; Vladislav Krupalnik; Sergey Viukov; Nofar Mor; Alejandro Aguilera-Castrejon; Dan Schneir; Jonathan Bayerl; Orel Mizrahi; Shani Peles; Shadi Tawil; Shashank Sathe; Aharon Nachshon; Tom Shani; Mirie Zerbib; Itay Kilimnik; Stefan Aigner; Archana Shankar; Jasmine R Mueller; Schraga Schwartz; Noam Stern-Ginossar; Gene W Yeo; Shay Geula; Noa Novershtern; Jacob H Hanna
Journal:  Genes Dev       Date:  2020-09-17       Impact factor: 11.361

7.  METTL3-mediated m6A modification regulates cell cycle progression of dental pulp stem cells.

Authors:  Haiyun Luo; Wenjing Liu; Yanli Zhang; Yeqing Yang; Xiao Jiang; Shiqing Wu; Longquan Shao
Journal:  Stem Cell Res Ther       Date:  2021-03-01       Impact factor: 6.832

8.  m6 A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase-specific transcripts.

Authors:  Meijie Qi; Haifeng Sun; Yueshuai Guo; Yu Zhou; Xueying Gu; Jiachuan Jin; Xiaoxu Chen; Fangzhu Wang; Honghui Ma; Xuejiang Guo; Hao Chen; Bin Shen
Journal:  Cell Prolif       Date:  2021-11-30       Impact factor: 6.831

9.  Predicting RNA 5-Methylcytosine Sites by Using Essential Sequence Features and Distributions.

Authors:  Lei Chen; ZhanDong Li; ShiQi Zhang; Yu-Hang Zhang; Tao Huang; Yu-Dong Cai
Journal:  Biomed Res Int       Date:  2022-01-13       Impact factor: 3.411

10.  The m6A-related gene signature for predicting the prognosis of breast cancer.

Authors:  Shanliang Zhong; Zhenzhong Lin; Huanwen Chen; Ling Mao; Jifeng Feng; Siying Zhou
Journal:  PeerJ       Date:  2021-06-04       Impact factor: 2.984
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