Co-relation Between Total Cholesterol, High Density Lipoprotein, Low Density Lipoprotein and Glycosylated Haemoglobin (HbA1c) in Diabetic Patients with Acute Coronary Syndrome (ACS).

BACKGROUND: Patients with diabetes & dyslipidaemia are at increased risk of developing coronary artery disease that many time manifests as life threatening ACS. AIM: To study co-relation between HbA1c &total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) in diabetic patients with acute coronary syndrome and also their co-relationship with severity of ACS independently. MATERIALS AND
METHOD: Blood samples of 51 known diabetic patients presented to emergency with ACS were sent for HbA1c & lipid profile estimation. All patients underwent coronary angiography. Obtained results were statistically analysed & co-related.
RESULTS: Patients were divided as having: 1. HDL <40, >40; 2. LDL <100, >100; 3. Total cholesterol <200, >200; 4. HbA1c 6.5-8.4, >8.4; 5. Single vessel disease (SVD) / multi vessel disease (MVD). Statistically significant direct co-relationship was found between HbA1c, LDL, Total cholesterol, ACS severity (SVD/MVD) & inverse co-relationship with HDL.
CONCLUSION: Severity & incidence of ACS in diabetic patients can be minimised by maintaining adequate glycaemic control & also by keeping circulating lipids under control. © Journal of the Association of Physicians of India 2011.