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Literature DB >> 3132492

Propylene glycol-induced side effects during intravenous nitroglycerin therapy.

H E Demey¹, R A Daelemans, G A Verpooten, M E De Broe, C M Van Campenhout, F V Lakiere, P J Schepens, L L Bossaert.

Abstract

Propylene glycol, an alcohol frequently used as a solvent in medical preparations, is considered non-toxic. We found that this solvent, used in a commercially available IV nitroglycerin solution, may cause hyperosmolality, hemolysis and lactic acidosis. The influence of kidney function as the main determinant in causing accumulation of this solvent and consequently hyperosmolality is emphasized. A review of the literature dealing with propylene glycol is given. The possible mechanisms of neurological disturbances occurring during IV nitroglycerin therapy are discussed.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1988 PMID： 3132492 DOI： 10.1007/bf00717993

Source DB: PubMed Journal: Intensive Care Med ISSN： 0342-4642 Impact factor: 17.440

34 in total

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Journal: Anesthesiology Date: 1979-07 Impact factor: 7.892

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Journal: Br Med J Date: 1961-06-24

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Journal: Lancet Date: 1984-06-16 Impact factor: 79.321

Review 5. Current concepts. Serum osmolality. Uses and limitations.

Authors: F J Gennari
Journal: N Engl J Med Date: 1984-01-12 Impact factor: 91.245

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Journal: Ann Intern Med Date: 1984-10 Impact factor: 25.391

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Journal: J Pediatr Date: 1978-09 Impact factor: 4.406

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Authors: M J Kelner; D N Bailey
Journal: J Anal Toxicol Date: 1985 Jan-Feb Impact factor: 3.367

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Authors: J M Ohar; A A Fowler; J B Selhorst; F L Glauser
Journal: Crit Care Med Date: 1985-10 Impact factor: 7.598

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Authors: J E Cottrell; B Gupta; H Rappaport; H Turndorf; J Ransohoff; E S Flamm
Journal: J Neurosurg Date: 1980-09 Impact factor: 5.115

11 in total

1. Propylene glycol produces excessive apoptosis in the developing mouse brain, alone and in combination with phenobarbital.

Authors: Karen Lau; Brant S Swiney; Nick Reeves; Kevin K Noguchi; Nuri B Farber
Journal: Pediatr Res Date: 2012-01 Impact factor: 3.756

2. Synergism and antagonism induced by three carrier solvents with t-retinoic acid and 6-aminonicotinamide using FETAX.

Authors: J R Rayburn; D J Fort; R McNew; J A Bantle
Journal: Bull Environ Contam Toxicol Date: 1991-04 Impact factor: 2.151

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Authors: I Huggon; I James; D Macrae
Journal: BMJ Date: 1990-07-07

4. Increase in venous complications associated with etomidate use during a propofol shortage: an example of clinically important adverse effects related to drug substitution.

Authors: Logan Kosarek; Stuart R Hart; Lucy Schultz; Neil Digiovanni
Journal: Ochsner J Date: 2011

8. Persistent lactic acidosis after chronic topical application of silver sulfadiazine in a pediatric burn patient: a review of the literature.

Authors: Monte S Willis; Bruce A Cairns; Ashley Purdy; Andrey V Bortsov; Samuel W Jones; Shiara M Ortiz-Pujols; Tina M Schade Willis; Benny L Joyner
Journal: Int J Burns Trauma Date: 2013-01-24

9. Pharmacokinetics of propylene glycol after rectal administration.

Authors: W J Kollöffel; L E Weekers; P B Goldhoorn
Journal: Pharm World Sci Date: 1996-06

10. Salvinorin A: A Mini Review of Physical and Chemical Properties Affecting Its Translation from Research to Clinical Applications in Humans.

Authors: Edward Orton; Renyu Liu
Journal: Transl Perioper Pain Med Date: 2014