Literature DB >> 31324436

Acid Fasting: Modulation of Mycobacterium tuberculosis Metabolism at Acidic pH.

Jacob J Baker1, Shelby J Dechow1, Robert B Abramovitch2.   

Abstract

Mycobacterium tuberculosis (Mtb) senses and adapts to acidic host environments during the course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often attenuated during macrophage or animal infections, supporting that these pathways are essential for pathogenesis and represent important new targets for drug discovery. This review examines a confluence of findings supporting that Mtb has restricted metabolism at acidic pH that results in the slowing of bacterial growth and changes in redox homeostasis. It is proposed that induction of the PhoPR regulon and anaplerotic metabolism, in concert with the restricted use of specific carbon sources, functions to counter reductive stress associated with acidic pH.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  metabolism; microbial pathogenesis; persistence; regulatory networks; stress response

Mesh：

Substances：

Year:  2019        PMID： 31324436      PMCID： PMC6800632          DOI： 10.1016/j.tim.2019.06.005

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


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Review 2.  Inhibiting DosRST as a new approach to tuberculosis therapy.

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Journal:  Future Med Chem       Date:  2020-02-13       Impact factor: 3.808

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5.  The Regulation of ManLAM-Related Gene Expression in Mycobacterium tuberculosis with Different Drug Resistance Profiles Following Isoniazid Treatment.

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6.  Systematic measurement of combination-drug landscapes to predict in vivo treatment outcomes for tuberculosis.

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9.  AC2P20 selectively kills Mycobacterium tuberculosis at acidic pH by depleting free thiols.

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10.  N-acetylcysteine (NAC) Attenuating Apoptosis and Autophagy in RAW264.7 Cells in Response to Incubation with Mycolic Acid from Bovine Mycobacterium tuberculosis Complex.

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