Pierre-Jean Bertrand1, Yvan Jamilloux1, René Ecochard2, Gaelle Richard-Colmant1, Mathieu Gerfaud-Valentin1, Martin Guillaud3, Philippe Denis3, Laurent Kodjikian3, Pascal Sève4. 1. Department of Internal Medicine, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, F-69004 Lyon, France. 2. Service de Biostatistique, Hospices Civils de Lyon & Laboratoire Biostatistique-Santé, UMR CNRS 5558, LBBE, Université Claude Bernard Lyon 1, F-69424 Lyon, France. 3. Department of Ophthalmology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, F-69004 Lyon, France. 4. Department of Internal Medicine, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, F-69004 Lyon, France; University Claude Bernard Lyon 1, HESPER EA 7425, F-69008 Lyon, France. Electronic address: pascal.seve@chu-lyon.fr.
Abstract
OBJECTIVE: Uveitis is the most common ophthalmological finding in the practice of rheumatology and clinical immunology. The condition is frequently idiopathic but about 60 causes of uveitis have been described. Our aim was to analyze the clinical patterns and etiologies of uveitis in a tertiary referral center. METHODS: The records of 912 consecutive patients referred to the department of internal medicine (Lyon University Hospital, Lyon, France) for the diagnostic work-up of uveitis were examined. Demographic, clinical, anatomical, and etiological features of uveitis were analyzed. RESULTS: The mean age at onset was 48.8 years; 59.8% of the patients were women and 78.2% were Caucasians. Anterior uveitis was the most common type of uveitis (40.6%), followed by panuveitis (31.7%), posterior (18.75%) and intermediate uveitis (9%). 46.9% of the patients had idiopathic uveitis. The most common etiologies were systemic diseases (37.3%), such as sarcoidosis (17.1%), HLA-B27-related uveitis and/or spondyloarthritis (12.5%), and tuberculosis (7.5%). CONCLUSION: We describe one of the largest cohorts of consecutive uveitis patients referred to a department of internal medicine. The high percentage of uveitis associated with underlying (systemic) diseases highlights the need for a multidisciplinary approach, in order to reduce the diagnostic delay.
OBJECTIVE:Uveitis is the most common ophthalmological finding in the practice of rheumatology and clinical immunology. The condition is frequently idiopathic but about 60 causes of uveitis have been described. Our aim was to analyze the clinical patterns and etiologies of uveitis in a tertiary referral center. METHODS: The records of 912 consecutive patients referred to the department of internal medicine (Lyon University Hospital, Lyon, France) for the diagnostic work-up of uveitis were examined. Demographic, clinical, anatomical, and etiological features of uveitis were analyzed. RESULTS: The mean age at onset was 48.8 years; 59.8% of the patients were women and 78.2% were Caucasians. Anterior uveitis was the most common type of uveitis (40.6%), followed by panuveitis (31.7%), posterior (18.75%) and intermediate uveitis (9%). 46.9% of the patients had idiopathic uveitis. The most common etiologies were systemic diseases (37.3%), such as sarcoidosis (17.1%), HLA-B27-related uveitis and/or spondyloarthritis (12.5%), and tuberculosis (7.5%). CONCLUSION: We describe one of the largest cohorts of consecutive uveitispatients referred to a department of internal medicine. The high percentage of uveitis associated with underlying (systemic) diseases highlights the need for a multidisciplinary approach, in order to reduce the diagnostic delay.
Authors: Martina Bonacini; Alessandra Soriano; Luca Cimino; Luca De Simone; Elena Bolletta; Fabrizio Gozzi; Francesco Muratore; Maria Nicastro; Lucia Belloni; Alessandro Zerbini; Luigi Fontana; Carlo Salvarani; Stefania Croci Journal: Front Immunol Date: 2020-03-10 Impact factor: 7.561
Authors: Elvis Hysa; Carlo Alberto Cutolo; Emanuele Gotelli; Greta Pacini; Carlotta Schenone; Elke O Kreps; Vanessa Smith; Maurizio Cutolo Journal: Eur J Clin Invest Date: 2021-05-05 Impact factor: 4.686