Literature DB >> 3132155

Coupling of TGF-beta-induced mitogenesis to G-protein activation in AKR-2B cells.

U S Murthy1, M A Anzano, J M Stadel, R Greig.   

Abstract

We have investigated the signal transduction mechanisms by which TGF-beta stimulates proliferation of AKR-2B murine fibroblasts. Enhanced incorporation of [3H]-thymidine into TGF-beta challenged cells was inhibited in a dose-dependent manner by pertussis toxin. EGF stimulated DNA synthesis was unaffected. Parallel biochemical analysis of pertussis toxin-challenged cells revealed that TGF-beta-induced inhibition of DNA synthesis was associated with ADP-ribosylation of a 41 kDa membrane component and a concomitant decrease in TGF-beta stimulated GTPase activity. These data, along with the observation that Gpp(NH)p decreases the affinity of the TGF-beta receptor for its ligand, strongly suggest that a GTP-binding protein is involved in TGF-beta-induced mitogenesis in AKR-2B cells.

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Year:  1988        PMID： 3132155     DOI： 10.1016/s0006-291x(88)80416-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Transforming growth factor beta 1 treatment of AKR-2B cells is coupled through a pertussis-toxin-sensitive G-protein(s).

Authors:  P H Howe; E B Leof
Journal:  Biochem J       Date:  1989-08-01       Impact factor: 3.857

2.  Inhibition of mink lung epithelial cell proliferation by transforming growth factor-beta is coupled through a pertussis-toxin-sensitive substrate.

Authors:  P H Howe; M R Cunningham; E B Leof
Journal:  Biochem J       Date:  1990-03-01       Impact factor: 3.857

3.  Opposite and independent actions of cyclic AMP and transforming growth factor beta in the regulation of type 1 plasminogen activator inhibitor expression.

Authors:  F W Thalacker; M Nilsen-Hamilton
Journal:  Biochem J       Date:  1992-11-01       Impact factor: 3.857

4.  Transforming growth factor beta decreases the rate of proliferation of rat vascular smooth muscle cells by extending the G2 phase of the cell cycle and delays the rise in cyclic AMP before entry into M phase.

Authors:  D J Grainger; P R Kemp; C M Witchell; P L Weissberg; J C Metcalfe
Journal:  Biochem J       Date:  1994-04-01       Impact factor: 3.857

5.  Regulation of fibroblast procollagen production. Transforming growth factor-beta 1 induces prostaglandin E2 but not procollagen synthesis via a pertussis toxin-sensitive G-protein.

Authors:  R J McAnulty; R C Chambers; G J Laurent
Journal:  Biochem J       Date:  1995-04-01       Impact factor: 3.857

6.  Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways.

Authors:  J Reibman; S Meixler; T C Lee; L I Gold; B N Cronstein; K A Haines; S L Kolasinski; G Weissmann
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

Review 7.  Transforming growth factor beta (TGF-beta) in inflammation: a cause and a cure.

Authors:  S M Wahl
Journal:  J Clin Immunol       Date:  1992-03       Impact factor: 8.317
  7 in total

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