Jueying Lin1, Yawei Liang2, Juexin Lin2. 1. Emergency Department, Zhongshan Hospital Xiamen University, No. 201, South Hubin Street, Siming District, Xiamen, 361000, Fujian, People's Republic of China. lin_jueying@hotmail.com. 2. Department of Statistics, University of South Carolina, Columbia, SC, USA.
Abstract
BACKGROUND: The purpose of our meta-analysis is to evaluate the endovascular therapy (EVT) in patients with cervical artery dissection (CAD)-related acute ischemic stroke (AIS) by comparing its efficacy and safety with the ones of intravenous thrombolysis (IVT). METHODS: A systematic search on EVT to CAD-related ischemic stroke is performed. The meta-analysis models are applied to calculate either the risk ratio (RR) with 95% confidence interval (CI) or pooled proportions with 95% CI of favorable functional outcome (mRS = 0-2), excellent functional outcome (mRS = 0-1), symptomatic intracranial hemorrhage (SICH), mortality and recurrent stroke between EVT and IVT in CAD-related stroke. The differences between the two treatment groups are analyzed by the pooled odds ratio value and Chi-squared test. RESULTS: A total of 190 patients given EVT and 139 IVT-alone patients are included. By comparing EVT alone and IVT alone, patients treated with EVT alone are more likely to experience favorable outcomes than those treated with IVT alone (71.2% vs 53.4%). Besides, there is no significant difference in excellent functional outcome, SICH, mortality and recurrent stroke between the EVT-alone and IVT-alone groups (all P > 0.05). Towards general EVT (EVT with or without IVT), the outcomes are not significantly different from those of IVT alone except for a higher mortality rate (10.2% vs 3.2%). CONCLUSION: Based on our findings, EVT is considered to be more efficacious than IVT for CAD-related AIS patients. Although EVT alone tends to be safe and promising, its safety needs to be further evaluated, particularly for EVT separating from IVT therapy.
BACKGROUND: The purpose of our meta-analysis is to evaluate the endovascular therapy (EVT) in patients with cervical artery dissection (CAD)-related acute ischemic stroke (AIS) by comparing its efficacy and safety with the ones of intravenous thrombolysis (IVT). METHODS: A systematic search on EVT to CAD-related ischemic stroke is performed. The meta-analysis models are applied to calculate either the risk ratio (RR) with 95% confidence interval (CI) or pooled proportions with 95% CI of favorable functional outcome (mRS = 0-2), excellent functional outcome (mRS = 0-1), symptomatic intracranial hemorrhage (SICH), mortality and recurrent stroke between EVT and IVT in CAD-related stroke. The differences between the two treatment groups are analyzed by the pooled odds ratio value and Chi-squared test. RESULTS: A total of 190 patients given EVT and 139 IVT-alone patients are included. By comparing EVT alone and IVT alone, patients treated with EVT alone are more likely to experience favorable outcomes than those treated with IVT alone (71.2% vs 53.4%). Besides, there is no significant difference in excellent functional outcome, SICH, mortality and recurrent stroke between the EVT-alone and IVT-alone groups (all P > 0.05). Towards general EVT (EVT with or without IVT), the outcomes are not significantly different from those of IVT alone except for a higher mortality rate (10.2% vs 3.2%). CONCLUSION: Based on our findings, EVT is considered to be more efficacious than IVT for CAD-related AISpatients. Although EVT alone tends to be safe and promising, its safety needs to be further evaluated, particularly for EVT separating from IVT therapy.
Authors: L A Crespo Araico; R Vera Lechuga; A Cruz-Culebras; C Matute Lozano; A de Felipe Mimbrera; P Agüero Rabes; E Viedma Guiard; C Estévez Fraga; J Masjuan Vallejo Journal: Neurologia (Engl Ed) Date: 2017-01-12
Authors: Jan P Vandenbroucke; Erik von Elm; Douglas G Altman; Peter C Gøtzsche; Cynthia D Mulrow; Stuart J Pocock; Charles Poole; James J Schlesselman; Matthias Egger Journal: Int J Surg Date: 2014-07-18 Impact factor: 6.071
Authors: Christopher Traenka; Simon Jung; Jan Gralla; Rebekka Kurmann; Christoph Stippich; Barbara Goeggel Simonetti; Henrik Gensicke; Hubertus Mueller; Karl Lovblad; Ashraf Eskandari; Francesco Puccinelli; Jochen Vehoff; Johannes Weber; Susanne Wegener; Levke Steiner; Georg Kägi; Andreas Luft; Roman Sztajzel; Urs Fischer; Leo H Bonati; Nils Peters; Patrik Michel; Philippe A Lyrer; Marcel Arnold; Stefan T Engelter Journal: Eur Stroke J Date: 2018-01-03
Authors: Ludwig Schlemm; Regina von Rennenberg; Eberhard Siebert; Georg Bohner; Fabian Flottmann; Gabor C Petzold; Götz Thomalla; Matthias Endres; Christian H Nolte Journal: Neurol Res Pract Date: 2021-05-03