Xiang Gao1, Edward Randell2, Yuan Tian3, Haicheng Zhou4, Guang Sun5. 1. College of Life Sciences, Qingdao University, No.308,Ningxia Road, Qingdao, Shandong, China. 2. Faculty of Medicine, Memorial University, 300 Prince Philip Drive, St. John's, NL, Canada. 3. Faculty of Medicine, Memorial University, 300 Prince Philip Drive, St. John's, NL, Canada; Xiangyang Central Hospital, Affiliated Hospital Of Hubei University of Arts and Science, Xiangyang, Hubei Province 441021, China. 4. Faculty of Medicine, Memorial University, 300 Prince Philip Drive, St. John's, NL, Canada; The Department of Endocrinology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. 5. Faculty of Medicine, Memorial University, 300 Prince Philip Drive, St. John's, NL, Canada. Electronic address: gsun@mun.ca.
Abstract
BACKGROUND: We investigated the relationships between serum choline and betaine levels with metabolic syndrome-related indices in the general population of Newfoundland. METHODS: 1081 adults were selected from the CODING study. Serum choline and betaine levels were measured. Major confounding factors were controlled in all analyses. RESULTS: Partial correlation and linear regression analysis showed that serum choline levels were positively associated with systolic blood pressure (r: 0.124), serum TG levels (r: 0.132) and negatively correlated with serum glucose levels (r: -0.121) in males (p < 0.01 for all). In females, serum choline levels were positively correlated with serum TG, TC and HDL levels (r: 0.104 to 0.148, p < 0.05 for all). Serum betaine levels were negatively associated with serum TG, TC, LDL and insulin levels, and with atherogenic index and HOMA-IR index in males (r: -0.081 to -0.179, p < 0.05 for all). In females, serum betaine levels were negatively associated with serum TG, hsCRP and insulin levels, and with HOMA-IR index (r: -0.092 to -0.213, p < 0.05 for all). Moreover, subjects with serum choline levels in the highest tertile showed highest serum TG levels and systolic blood pressure in males, and highest serum lipids levels in females. Subjects with the highest serum betaine levels had the lowest serum lipids levels, atherogenic index, IR severity in males, and the lowest serum TG and hsCRP levels, and IR severity in females. CONCLUSION: Low serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in general adults.
BACKGROUND: We investigated the relationships between serum choline and betaine levels with metabolic syndrome-related indices in the general population of Newfoundland. METHODS: 1081 adults were selected from the CODING study. Serum choline and betaine levels were measured. Major confounding factors were controlled in all analyses. RESULTS: Partial correlation and linear regression analysis showed that serum choline levels were positively associated with systolic blood pressure (r: 0.124), serum TG levels (r: 0.132) and negatively correlated with serum glucose levels (r: -0.121) in males (p < 0.01 for all). In females, serum choline levels were positively correlated with serum TG, TC and HDL levels (r: 0.104 to 0.148, p < 0.05 for all). Serum betaine levels were negatively associated with serum TG, TC, LDL and insulin levels, and with atherogenic index and HOMA-IR index in males (r: -0.081 to -0.179, p < 0.05 for all). In females, serum betaine levels were negatively associated with serum TG, hsCRP and insulin levels, and with HOMA-IR index (r: -0.092 to -0.213, p < 0.05 for all). Moreover, subjects with serum choline levels in the highest tertile showed highest serum TG levels and systolic blood pressure in males, and highest serum lipids levels in females. Subjects with the highest serum betaine levels had the lowest serum lipids levels, atherogenic index, IR severity in males, and the lowest serum TG and hsCRP levels, and IR severity in females. CONCLUSION: Low serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in general adults.
Authors: Ming Liu; Yiheng Huang; Hongwei Zhang; Dawn Aitken; Michael C Nevitt; Jason S Rockel; Jean-Pierre Pelletier; Cora E Lewis; James Torner; Yoga Raja Rampersaud; Anthony V Perruccio; Nizar N Mahomed; Andrew Furey; Edward W Randell; Proton Rahman; Guang Sun; Johanne Martel-Pelletier; Mohit Kapoor; Graeme Jones; David Felson; Dake Qi; Guangju Zhai Journal: Metabolites Date: 2022-04-07
Authors: Julia Hernandez-Baixauli; Sergio Quesada-Vázquez; Roger Mariné-Casadó; Katherine Gil Cardoso; Antoni Caimari; Josep M Del Bas; Xavier Escoté; Laura Baselga-Escudero Journal: Nutrients Date: 2020-03-18 Impact factor: 5.717