OBJECTIVES: This Liverpool Healthy Lung Programme is a response to high rates of lung cancer and respiratory diseases locally and aims to diagnose lung cancer at an earlier stage by proactive approach to those at high risk of lung cancer. The objective of this study is to evaluate the programme in terms of its likely effect on mortality from lung cancer and its delivery to deprived populations. METHODS: Persons aged 58-75 years, with a history of smoking or a diagnosis of chronic obstructive pulmonary disease (COPD)2 according to general practice records were invited for lung health check in a community health hub setting. A detailed risk assessment and spirometry were performed in eligible patients. Those with a 5% or greater five-year risk of lung cancer were referred for a low dose CT3 scan. RESULTS: A total of 4 566 subjects attended the appointment for risk assessment and 3 591 (79%) consented to data sharing. More than 80% of the patients were in the most deprived quintile of the index of multiple deprivation. Of those attending, 63% underwent spirometry and 43% were recommended for a CT scan. A total of 25 cancers were diagnosed, of which 16 (64%) were stage I. Comparison with the national stage distribution implied that the programme was reducing lung cancer mortality by 22%. CONCLUSIONS: Community based proactive approaches to early diagnosis of lung cancer in health deprived regions are likely to be effective in early detection of lung cancer.
OBJECTIVES: This Liverpool Healthy Lung Programme is a response to high rates of lung cancer and respiratory diseases locally and aims to diagnose lung cancer at an earlier stage by proactive approach to those at high risk of lung cancer. The objective of this study is to evaluate the programme in terms of its likely effect on mortality from lung cancer and its delivery to deprived populations. METHODS:Persons aged 58-75 years, with a history of smoking or a diagnosis of chronic obstructive pulmonary disease (COPD)2 according to general practice records were invited for lung health check in a community health hub setting. A detailed risk assessment and spirometry were performed in eligible patients. Those with a 5% or greater five-year risk of lung cancer were referred for a low dose CT3 scan. RESULTS: A total of 4 566 subjects attended the appointment for risk assessment and 3 591 (79%) consented to data sharing. More than 80% of the patients were in the most deprived quintile of the index of multiple deprivation. Of those attending, 63% underwent spirometry and 43% were recommended for a CT scan. A total of 25 cancers were diagnosed, of which 16 (64%) were stage I. Comparison with the national stage distribution implied that the programme was reducing lung cancer mortality by 22%. CONCLUSIONS: Community based proactive approaches to early diagnosis of lung cancer in health deprived regions are likely to be effective in early detection of lung cancer.
Authors: Matthijs Oudkerk; ShiYuan Liu; Marjolein A Heuvelmans; Joan E Walter; John K Field Journal: Nat Rev Clin Oncol Date: 2020-10-12 Impact factor: 66.675
Authors: Eduardo Edelman Saul; Raquel B Guerra; Michelle Edelman Saul; Laercio Lopes da Silva; Gabriel F P Aleixo; Raquel M K Matuda; Gilberto Lopes Journal: Nat Cancer Date: 2020-11-30
Authors: Hilary A Robbins; Karine Alcala; Anthony J Swerdlow; Minouk J Schoemaker; Nick Wareham; Ruth C Travis; Philip A J Crosbie; Matthew Callister; David R Baldwin; Rebecca Landy; Mattias Johansson Journal: Br J Cancer Date: 2021-04-12 Impact factor: 9.075
Authors: Giulia Veronesi; David R Baldwin; Claudia I Henschke; Simone Ghislandi; Sergio Iavicoli; Matthijs Oudkerk; Harry J De Koning; Joseph Shemesh; John K Field; Javier J Zulueta; Denis Horgan; Lucia Fiestas Navarrete; Maurizio Valentino Infante; Pierluigi Novellis; Rachael L Murray; Nir Peled; Cristiano Rampinelli; Gaetano Rocco; Witold Rzyman; Giorgio Vittorio Scagliotti; Martin C Tammemagi; Luca Bertolaccini; Natthaya Triphuridet; Rowena Yip; Alexia Rossi; Suresh Senan; Giuseppe Ferrante; Kate Brain; Carlijn van der Aalst; Lorenzo Bonomo; Dario Consonni; Jan P Van Meerbeeck; Patrick Maisonneuve; Silvia Novello; Anand Devaraj; Zaigham Saghir; Giuseppe Pelosi Journal: Cancers (Basel) Date: 2020-06-24 Impact factor: 6.639
Authors: Rudolf M Huber; Milena Cavic; Anna Kerpel-Fronius; Lucia Viola; John Field; Long Jiang; Ella A Kazerooni; Coenraad F N Koegelenberg; Anant Mohan; Ricardo Sales Dos Santos; Luigi Ventura; Murry Wynes; Dawei Yang; Javier Zulueta; Choon-Taek Lee; Martin C Tammemägi; Claudia I Henschke; Stephen Lam Journal: J Thorac Oncol Date: 2021-12-03 Impact factor: 15.609
Authors: John K Field; Daniel Vulkan; Michael P A Davies; David R Baldwin; Kate E Brain; Anand Devaraj; Tim Eisen; John Gosney; Beverley A Green; John A Holemans; Terry Kavanagh; Keith M Kerr; Martin Ledson; Kate J Lifford; Fiona E McRonald; Arjun Nair; Richard D Page; Mahesh K B Parmar; Doris M Rassl; Robert C Rintoul; Nicholas J Screaton; Nicholas J Wald; David Weller; David K Whynes; Paula R Williamson; Gasham Yadegarfar; Rhian Gabe; Stephen W Duffy Journal: Lancet Reg Health Eur Date: 2021-09-11
Authors: John K Field; Harry deKoning; Mattijs Oudkerk; Sadia Anwar; James Mulshine; Ugo Pastorino; Wilfried Eberhardt; Helmut Prosch Journal: ESMO Open Date: 2019-10-13