Chen Rui-Hua1, Peng Yong-de1, Jiang Xiao-Zhen2, Jason Chen3, Zhou Bin2. 1. Department of Endocrinology, Shanghai General Hospital of Nanjing Medical University, Nanjing, China. 2. Department of Endocrinology, Shanghai Pudong New Area People's Hospital, Shanghai, China. 3. JMP China Division, SAS Institute Inc, Cary, NC, USA.
Abstract
PURPOSE: To determine the association of serum insulin-like growth factor 1 (IGF-1) and vitamin D levels with cognition status in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 173 patients with T2DM were recruited and divided into mild cognitive impairment (MCI) group (n = 94) and normal cognition (NC) group (n = 79). Levels of IGF-1 and 25(OH)D were measured and compared, and the correlations among IGF-1, 25(OH)D, and cognitive function were analyzed. RESULTS: Insulin-like growth factor 1 and 25(OH)D levels significantly decreased in MCI group than those in the NC group (both P < .001). Multiple stepwise regression analysis revealed that IGF-1 (β = .146, P < .001) and 25(OH)D (β = .199, P < .001) independently predicted Montreal Cognitive Assessment (MoCA) scores. Partial least square regression showed that contributions of both 25(OH)D (P < .001) and IGF-1 (P < .001) to MoCA scores were significant, while no cross-effect was observed between them (P = .714). CONCLUSIONS: Low serum IGF-1 and 25(OH)D levels may separately predict poor cognitive performance in patients with diabetes.
PURPOSE: To determine the association of serum insulin-like growth factor 1 (IGF-1) and vitamin D levels with cognition status in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 173 patients with T2DM were recruited and divided into mild cognitive impairment (MCI) group (n = 94) and normal cognition (NC) group (n = 79). Levels of IGF-1 and 25(OH)D were measured and compared, and the correlations among IGF-1, 25(OH)D, and cognitive function were analyzed. RESULTS:Insulin-like growth factor 1 and 25(OH)D levels significantly decreased in MCI group than those in the NC group (both P < .001). Multiple stepwise regression analysis revealed that IGF-1 (β = .146, P < .001) and 25(OH)D (β = .199, P < .001) independently predicted Montreal Cognitive Assessment (MoCA) scores. Partial least square regression showed that contributions of both 25(OH)D (P < .001) and IGF-1 (P < .001) to MoCA scores were significant, while no cross-effect was observed between them (P = .714). CONCLUSIONS: Low serum IGF-1 and 25(OH)D levels may separately predict poor cognitive performance in patients with diabetes.
Entities:
Keywords:
IGF-1; Montreal Cognitive Assessment; diabetes mellitus; mental status and dementia tests; mild cognitive impairment; type 2; vitamin D