Literature DB >> 31319351

The chemical synthesis of human milk oligosaccharides: Lacto-N-neotetraose (Galβ1→4GlcNAcβ1→3Galβ1→4Glc).

Mithila D Bandara1, Keith J Stine1, Alexei V Demchenko2.   

Abstract

The discovery of innovative methods that offer new capabilities for obtaining individual oligosaccharides from human milk will help to improve understanding their roles and boost practical applications. The total chemical synthesis of lacto-N-neotetraose (LNnT) has been completed using both linear and convergent strategies. The donor and acceptor protecting and leaving group combinations were found to be of paramount significance to successful couplings.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2019        PMID： 31319351      PMCID： PMC6717531          DOI： 10.1016/j.carres.2019.107743

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN： 0008-6215            Impact factor:   2.104


  6 in total

1.  Like mother, like microbe: human milk oligosaccharide mediated microbiome symbiosis.

Authors:  Schuyler A Chambers; Steven D Townsend
Journal:  Biochem Soc Trans       Date:  2020-06-30       Impact factor: 5.407

2.  Picoloyl protecting group in synthesis: focus on a highly chemoselective catalytic removal.

Authors:  Scott A Geringer; Michael P Mannino; Mithila D Bandara; Alexei V Demchenko
Journal:  Org Biomol Chem       Date:  2020-07-01       Impact factor: 3.876

3.  Chemical Synthesis of Human Milk Oligosaccharides: Lacto-N-hexaose Galβ1→3GlcNAcβ1→3 [Galβ1→4GlcNAcβ1→6] Galβ1→4Glc.

Authors:  Mithila D Bandara; Keith J Stine; Alexei V Demchenko
Journal:  J Org Chem       Date:  2019-12-05       Impact factor: 4.354

4.  The chemical synthesis of human milk oligosaccharides: Lacto-N-tetraose (Galβ1→3GlcNAcβ1→3Galβ1→4Glc).

Authors:  Mithila D Bandara; Keith J Stine; Alexei V Demchenko
Journal:  Carbohydr Res       Date:  2019-09-25       Impact factor: 2.104

5.  Substrate and Process Engineering for Biocatalytic Synthesis and Facile Purification of Human Milk Oligosaccharides.

Authors:  Yuanyuan Bai; Xiaohong Yang; Hai Yu; Xi Chen
Journal:  ChemSusChem       Date:  2022-02-18       Impact factor: 9.140

6.  A Comparison of Two Structurally Related Human Milk Oligosaccharide Conjugates in a Model of Diet-Induced Obesity.

Authors:  Jessica Ramadhin; Vanessa Silva-Moraes; Tamas Nagy; Thomas Norberg; Donald Harn
Journal:  Front Immunol       Date:  2021-05-20       Impact factor: 7.561
  6 in total

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