Mei-Hsuan Lee1, Yu-Tang Gao2, Yu-Han Huang1, Emma E McGee3,4, Tram Lam5, Bingsheng Wang6, Ming-Chang Shen7, Asif Rashid8, Ruth M Pfeiffer9, Ann W Hsing10, Jill Koshiol3. 1. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. 2. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China. 3. Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD. 4. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA. 5. Division of Cancer Control and Population Sciences, Epidemiology and Genomics Research Program, National Cancer Institute, National Institutes of Health, Rockville, MD. 6. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. 7. Department of Pathology, Shanghai Cancer Center, Fudan University, Shanghai, China. 8. Department of Pathology, MD Anderson Cancer Center, Houston, TX. 9. Biostatistics Branch, National Cancer Institute, National Institutes of Health, Rockville, MD. 10. Stanford Cancer Institute, Stanford University, Stanford, CA.
Abstract
BACKGROUND AND AIMS: Exposure to metals may promote the risk for cancers. We evaluated the associations of a broad spectrum of metals with gallbladder cancer (GBC) and gallstones. APPROACH AND RESULTS: A total of 259 patients with GBC, 701 patients with gallstones, and 851 population-based controls were enrolled in Shanghai, China. A metallome panel was used to simultaneously detect 18 metals in serum through inductively coupled plasma-mass spectrometry. Logistic regression models were used to estimate crude or adjusted odds ratios (ORadj ) with 95% confidence intervals (CIs) for the association between metal levels and gallbladder disease. Among the 18 metals tested, 12 were significantly associated with GBC and six with gallstones (Pcorrected < 0.002). Boron, lithium, molybdenum, and arsenic levels were associated with GBC compared to gallstones as well as with gallstones compared to population-based controls. Elevated levels of cadmium, chromium, copper, molybdenum, and vanadium were positively associated with GBC versus gallstones; and the ORadj for the highest tertile (T3) compared to the lowest tertile (T1) ranged from 1.80 to 7.28, with evidence of dose-response trends (P < 0.05). Arsenic, boron, iron, lithium, magnesium, selenium, and sulfur were inversely associated with GBC, with the T3 versus T1 ORadj ranging from 0.20 to 0.69. Arsenic, boron, calcium, lithium, molybdenum, and phosphorus were negatively associated with gallstones, with the T3 versus T1 ORadj ranging from 0.50 to 0.75 (P < 0.05). CONCLUSIONS: Metals were associated with both GBC and gallstones, providing cross-sectional evidence of association across the natural history of disease. Longitudinal studies are needed to evaluate the temporality of metal exposure and gallbladder diseases and to investigate the mechanisms of disease pathogenesis.
BACKGROUND AND AIMS: Exposure to metals may promote the risk for cancers. We evaluated the associations of a broad spectrum of metals with gallbladder cancer (GBC) and gallstones. APPROACH AND RESULTS: A total of 259 patients with GBC, 701 patients with gallstones, and 851 population-based controls were enrolled in Shanghai, China. A metallome panel was used to simultaneously detect 18 metals in serum through inductively coupled plasma-mass spectrometry. Logistic regression models were used to estimate crude or adjusted odds ratios (ORadj ) with 95% confidence intervals (CIs) for the association between metal levels and gallbladder disease. Among the 18 metals tested, 12 were significantly associated with GBC and six with gallstones (Pcorrected < 0.002). Boron, lithium, molybdenum, and arsenic levels were associated with GBC compared to gallstones as well as with gallstones compared to population-based controls. Elevated levels of cadmium, chromium, copper, molybdenum, and vanadium were positively associated with GBC versus gallstones; and the ORadj for the highest tertile (T3) compared to the lowest tertile (T1) ranged from 1.80 to 7.28, with evidence of dose-response trends (P < 0.05). Arsenic, boron, iron, lithium, magnesium, selenium, and sulfur were inversely associated with GBC, with the T3 versus T1 ORadj ranging from 0.20 to 0.69. Arsenic, boron, calcium, lithium, molybdenum, and phosphorus were negatively associated with gallstones, with the T3 versus T1 ORadj ranging from 0.50 to 0.75 (P < 0.05). CONCLUSIONS: Metals were associated with both GBC and gallstones, providing cross-sectional evidence of association across the natural history of disease. Longitudinal studies are needed to evaluate the temporality of metal exposure and gallbladder diseases and to investigate the mechanisms of disease pathogenesis.
Authors: Vivien Taylor; Britton Goodale; Andrea Raab; Tanja Schwerdtle; Ken Reimer; Sean Conklin; Margaret R Karagas; Kevin A Francesconi Journal: Sci Total Environ Date: 2016-12-24 Impact factor: 7.963
Authors: Jill Koshiol; Aniela Wozniak; Paz Cook; Christina Adaniel; Johanna Acevedo; Lorena Azócar; Ann W Hsing; Juan C Roa; Marcela F Pasetti; Juan F Miquel; Myron M Levine; Catterina Ferreccio Journal: Cancer Med Date: 2016-10-11 Impact factor: 4.452
Authors: Shakira M Nelson; Yu-Tang Gao; Leticia M Nogueira; Ming-Chang Shen; Bingsheng Wang; Asif Rashid; Ann W Hsing; Jill Koshiol Journal: PLoS One Date: 2017-03-13 Impact factor: 3.240
Authors: Jill Koshiol; Vanessa Van De Wyngard; Emma E McGee; Paz Cook; Ruth M Pfeiffer; Noldy Mardones; Karie Medina; Vanessa Olivo; Karen Pettit; Sarah S Jackson; Fabio Paredes; Raúl Sanchez; Andrea Huidobro; Miguel Villaseca; Enrique Bellolio; Hector Losada; Juan Carlos Roa; Allan Hildesheim; Juan Carlos Araya; Catterina Ferreccio Journal: Am J Epidemiol Date: 2021-02-01 Impact factor: 4.897