Hannah K Steere1, Lien Quach, Laura Grande, Jonathan F Bean. 1. From the Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts (HKS, JFB); Spaulding Rehabilitation Hospital, Charlestown, Massachusetts (HKS, JFB); Massachusetts Veterans Epidemiology Research and Information Center, Geriatric Research Education and Clinical Center, Boston, Massachusetts (LQ, JFB); Psychology Service, VA Boston Healthcare System, Boston, Massachusetts (LG); and Department of Psychiatry, School of Medicine, Boston University, Boston, Massachusetts (LG).
Abstract
OBJECTIVE: We investigated the associations between mild cognitive impairment (MCI), social engagement (SE), and mobility. DESIGN: We evaluated data from a cohort study of older adult primary care patients (N = 430). Outcomes included self-reported function (Late-Life Function Instrument [LLFI]) and performance-based mobility (Short Physical Performance Battery score [SPPB]). Linear regression models evaluated the association between MCI and mobility, MCI and SE, mobility measures and SE, and whether SE mediated the association between MCI status and mobility. RESULTS: Participants with MCI had significantly lower mobility and lower SE as compared with those without MCI (LLFI: 53.5 vs. 56.9, P < 0.001; SPPB: 7.9 vs. 9.3, P < 0.001; SE score: 44.9 vs. 49.0, P < 0.001). Mild cognitive impairment was significantly associated with both LLFI and SPPB (LLFI β = -2.93, P < 0.001; SPPB β = -1.26, P < 0.001) and SE (β = -3.20, P < 0.001). Social engagement was significantly associated with both LLFI and SPPB (LLFI β = 0.22; P < 0.001; SPPB β = 0.08; P < 0.001). There was a positive association between SE and mobility (P< 0.05). A mediator effect of SE was supported when evaluating the association between MCI and mobility. CONCLUSIONS: Among older adult primary care patients at risk for mobility decline, higher levels of SE mitigate the association between MCI and mobility.
OBJECTIVE: We investigated the associations between mild cognitive impairment (MCI), social engagement (SE), and mobility. DESIGN: We evaluated data from a cohort study of older adult primary care patients (N = 430). Outcomes included self-reported function (Late-Life Function Instrument [LLFI]) and performance-based mobility (Short Physical Performance Battery score [SPPB]). Linear regression models evaluated the association between MCI and mobility, MCI and SE, mobility measures and SE, and whether SE mediated the association between MCI status and mobility. RESULTS:Participants with MCI had significantly lower mobility and lower SE as compared with those without MCI (LLFI: 53.5 vs. 56.9, P < 0.001; SPPB: 7.9 vs. 9.3, P < 0.001; SE score: 44.9 vs. 49.0, P < 0.001). Mild cognitive impairment was significantly associated with both LLFI and SPPB (LLFI β = -2.93, P < 0.001; SPPB β = -1.26, P < 0.001) and SE (β = -3.20, P < 0.001). Social engagement was significantly associated with both LLFI and SPPB (LLFI β = 0.22; P < 0.001; SPPB β = 0.08; P < 0.001). There was a positive association between SE and mobility (P< 0.05). A mediator effect of SE was supported when evaluating the association between MCI and mobility. CONCLUSIONS: Among older adult primary care patients at risk for mobility decline, higher levels of SE mitigate the association between MCI and mobility.
Authors: J M Guralnik; L Ferrucci; C F Pieper; S G Leveille; K S Markides; G V Ostir; S Studenski; L F Berkman; R B Wallace Journal: J Gerontol A Biol Sci Med Sci Date: 2000-04 Impact factor: 6.053
Authors: Alan M Jette; Stephen M Haley; Wendy J Coster; Jill T Kooyoomjian; Suzette Levenson; Tim Heeren; Jacqueline Ashba Journal: J Gerontol A Biol Sci Med Sci Date: 2002-04 Impact factor: 6.053
Authors: Stephen M Haley; Alan M Jette; Wendy J Coster; Jill T Kooyoomjian; Suzette Levenson; Tim Heeren; Jacqueline Ashba Journal: J Gerontol A Biol Sci Med Sci Date: 2002-04 Impact factor: 6.053