Literature DB >> 31318128

Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura (HERCULES trial).

L J Estcourt1,2.   

Abstract

CLINICAL QUESTION: In people with acquired thrombotic thrombocytopenic purpura (TTP), does caplacizumab decrease the time to normalisation of the platelet count and the risk of death and complications caused by thrombotic events and organ damage? EVIDENCE FROM TRIAL: In adults with acquired TTP, caplacizumab decreased the time to normalisation of the platelet count and decreased the risk of TTP-related death and recurrence of TTP.
© 2019 British Blood Transfusion Society.

Entities:  

Keywords:  RCT; caplacizumab; plasma exchange; thrombotic thrombocytopenic pupura

Year:  2019        PMID: 31318128     DOI: 10.1111/tme.12615

Source DB:  PubMed          Journal:  Transfus Med        ISSN: 0958-7578            Impact factor:   2.019


  2 in total

Review 1.  ADAMTS13 conformations and mechanism of inhibition in immune thrombotic thrombocytopenic purpura.

Authors:  Konstantine Halkidis; X Long Zheng
Journal:  J Thromb Haemost       Date:  2022-08-03       Impact factor: 16.036

2.  Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain.

Authors:  Xiaojing Chi; Xiuying Liu; Conghui Wang; Xinhui Zhang; Xiang Li; Jianhua Hou; Lili Ren; Qi Jin; Jianwei Wang; Wei Yang
Journal:  Nat Commun       Date:  2020-09-10       Impact factor: 14.919

  2 in total

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